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Heart Failure: Advanced Development in Genetics and Epigenetics
Heart failure (HF) is a complex pathophysiological syndrome that arises from a primary defect in the ability of the heart to take in and/or eject sufficient blood. Genetic mutations associated with familial dilated cardiomyopathy, hypertrophic cardiomyopathy, and arrhythmogenic right ventricular car...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407520/ https://www.ncbi.nlm.nih.gov/pubmed/25949994 http://dx.doi.org/10.1155/2015/352734 |
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author | Yang, Jian Xu, Wei-wei Hu, Shen-jiang |
author_facet | Yang, Jian Xu, Wei-wei Hu, Shen-jiang |
author_sort | Yang, Jian |
collection | PubMed |
description | Heart failure (HF) is a complex pathophysiological syndrome that arises from a primary defect in the ability of the heart to take in and/or eject sufficient blood. Genetic mutations associated with familial dilated cardiomyopathy, hypertrophic cardiomyopathy, and arrhythmogenic right ventricular cardiomyopathy can contribute to the various pathologies of HF. Therefore, genetic screening could be an approach for guiding individualized therapies and surveillance. In addition, epigenetic regulation occurs via key mechanisms, including ATP-dependent chromatin remodeling, DNA methylation, histone modification, and RNA-based mechanisms. MicroRNA is also a hot spot in HF research. This review gives an overview of genetic mutations associated with cardiomyopathy and the roles of some epigenetic mechanisms in HF. |
format | Online Article Text |
id | pubmed-4407520 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-44075202015-05-06 Heart Failure: Advanced Development in Genetics and Epigenetics Yang, Jian Xu, Wei-wei Hu, Shen-jiang Biomed Res Int Review Article Heart failure (HF) is a complex pathophysiological syndrome that arises from a primary defect in the ability of the heart to take in and/or eject sufficient blood. Genetic mutations associated with familial dilated cardiomyopathy, hypertrophic cardiomyopathy, and arrhythmogenic right ventricular cardiomyopathy can contribute to the various pathologies of HF. Therefore, genetic screening could be an approach for guiding individualized therapies and surveillance. In addition, epigenetic regulation occurs via key mechanisms, including ATP-dependent chromatin remodeling, DNA methylation, histone modification, and RNA-based mechanisms. MicroRNA is also a hot spot in HF research. This review gives an overview of genetic mutations associated with cardiomyopathy and the roles of some epigenetic mechanisms in HF. Hindawi Publishing Corporation 2015 2015-04-09 /pmc/articles/PMC4407520/ /pubmed/25949994 http://dx.doi.org/10.1155/2015/352734 Text en Copyright © 2015 Jian Yang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Yang, Jian Xu, Wei-wei Hu, Shen-jiang Heart Failure: Advanced Development in Genetics and Epigenetics |
title | Heart Failure: Advanced Development in Genetics and Epigenetics |
title_full | Heart Failure: Advanced Development in Genetics and Epigenetics |
title_fullStr | Heart Failure: Advanced Development in Genetics and Epigenetics |
title_full_unstemmed | Heart Failure: Advanced Development in Genetics and Epigenetics |
title_short | Heart Failure: Advanced Development in Genetics and Epigenetics |
title_sort | heart failure: advanced development in genetics and epigenetics |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407520/ https://www.ncbi.nlm.nih.gov/pubmed/25949994 http://dx.doi.org/10.1155/2015/352734 |
work_keys_str_mv | AT yangjian heartfailureadvanceddevelopmentingeneticsandepigenetics AT xuweiwei heartfailureadvanceddevelopmentingeneticsandepigenetics AT hushenjiang heartfailureadvanceddevelopmentingeneticsandepigenetics |