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Heart Failure: Advanced Development in Genetics and Epigenetics

Heart failure (HF) is a complex pathophysiological syndrome that arises from a primary defect in the ability of the heart to take in and/or eject sufficient blood. Genetic mutations associated with familial dilated cardiomyopathy, hypertrophic cardiomyopathy, and arrhythmogenic right ventricular car...

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Detalles Bibliográficos
Autores principales: Yang, Jian, Xu, Wei-wei, Hu, Shen-jiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407520/
https://www.ncbi.nlm.nih.gov/pubmed/25949994
http://dx.doi.org/10.1155/2015/352734
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author Yang, Jian
Xu, Wei-wei
Hu, Shen-jiang
author_facet Yang, Jian
Xu, Wei-wei
Hu, Shen-jiang
author_sort Yang, Jian
collection PubMed
description Heart failure (HF) is a complex pathophysiological syndrome that arises from a primary defect in the ability of the heart to take in and/or eject sufficient blood. Genetic mutations associated with familial dilated cardiomyopathy, hypertrophic cardiomyopathy, and arrhythmogenic right ventricular cardiomyopathy can contribute to the various pathologies of HF. Therefore, genetic screening could be an approach for guiding individualized therapies and surveillance. In addition, epigenetic regulation occurs via key mechanisms, including ATP-dependent chromatin remodeling, DNA methylation, histone modification, and RNA-based mechanisms. MicroRNA is also a hot spot in HF research. This review gives an overview of genetic mutations associated with cardiomyopathy and the roles of some epigenetic mechanisms in HF.
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spelling pubmed-44075202015-05-06 Heart Failure: Advanced Development in Genetics and Epigenetics Yang, Jian Xu, Wei-wei Hu, Shen-jiang Biomed Res Int Review Article Heart failure (HF) is a complex pathophysiological syndrome that arises from a primary defect in the ability of the heart to take in and/or eject sufficient blood. Genetic mutations associated with familial dilated cardiomyopathy, hypertrophic cardiomyopathy, and arrhythmogenic right ventricular cardiomyopathy can contribute to the various pathologies of HF. Therefore, genetic screening could be an approach for guiding individualized therapies and surveillance. In addition, epigenetic regulation occurs via key mechanisms, including ATP-dependent chromatin remodeling, DNA methylation, histone modification, and RNA-based mechanisms. MicroRNA is also a hot spot in HF research. This review gives an overview of genetic mutations associated with cardiomyopathy and the roles of some epigenetic mechanisms in HF. Hindawi Publishing Corporation 2015 2015-04-09 /pmc/articles/PMC4407520/ /pubmed/25949994 http://dx.doi.org/10.1155/2015/352734 Text en Copyright © 2015 Jian Yang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Yang, Jian
Xu, Wei-wei
Hu, Shen-jiang
Heart Failure: Advanced Development in Genetics and Epigenetics
title Heart Failure: Advanced Development in Genetics and Epigenetics
title_full Heart Failure: Advanced Development in Genetics and Epigenetics
title_fullStr Heart Failure: Advanced Development in Genetics and Epigenetics
title_full_unstemmed Heart Failure: Advanced Development in Genetics and Epigenetics
title_short Heart Failure: Advanced Development in Genetics and Epigenetics
title_sort heart failure: advanced development in genetics and epigenetics
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407520/
https://www.ncbi.nlm.nih.gov/pubmed/25949994
http://dx.doi.org/10.1155/2015/352734
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