Cargando…

Protective Role of Nuclear Factor E2-Related Factor 2 against Acute Oxidative Stress-Induced Pancreatic β-Cell Damage

Oxidative stress is implicated in the pathogenesis of pancreatic β-cell dysfunction that occurs in both type 1 and type 2 diabetes. Nuclear factor E2-related factor 2 (NRF2) is a master regulator in the cellular adaptive response to oxidative stress. The present study found that MIN6 β-cells with st...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fu, Jingqi, Zheng, Hongzhi, Wang, Huihui, Yang, Bei, Zhao, Rui, Lu, Chunwei, Liu, Zhiyuan, Hou, Yongyong, Xu, Yuanyuan, Zhang, Qiang, Qu, Weidong, Pi, Jingbo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407529/ https://www.ncbi.nlm.nih.gov/pubmed/25949772 http://dx.doi.org/10.1155/2015/639191

Ejemplares similares

Single-nucleus RNA-sequencing reveals NRF1/NFE2L1 as a key factor determining the thermogenesis and cellular heterogeneity and dynamics of brown adipose tissues in mice
por: Shen, Wei, et al.
Publicado: (2023)

NRF2 Is a Potential Modulator of Hyperresistance to Arsenic Toxicity in Stem-Like Keratinocytes
por: Wu, Xiafang, et al.
Publicado: (2017)

Is Nuclear Factor Erythroid 2-Related Factor 2 a Target for the Intervention of Cytokine Storms?
por: Liu, Zihang, et al.
Publicado: (2023)

The roles of NFE2L1 in adipocytes: Structural and mechanistic insight from cell and mouse models
por: Ren, Suping, et al.
Publicado: (2021)

Adipose Deficiency of Nrf2 in ob/ob Mice Results in Severe Metabolic Syndrome
por: Xue, Peng, et al.
Publicado: (2013)

Hepatocyte-specific Nrf2 deficiency mitigates high-fat diet-induced hepatic steatosis: Involvement of reduced PPARγ expression
por: Li, Lu, et al.
Publicado: (2019)

Association between Arsenic Suppression of Adipogenesis and Induction of CHOP10 via the Endoplasmic Reticulum Stress Response
por: Hou, Yongyong, et al.
Publicado: (2012)

CNC-bZIP protein NFE2L1 regulates osteoclast differentiation in antioxidant-dependent and independent manners
por: Liu, Zhiyuan, et al.
Publicado: (2021)

Long isoforms of NRF1 negatively regulate adipogenesis via suppression of PPARγ expression
por: Xue, Peng, et al.
Publicado: (2019)

Cross-Regulations among NRFs and KEAP1 and Effects of their Silencing on Arsenic-Induced Antioxidant Response and Cytotoxicity in Human Keratinocytes
por: Zhao, Rui, et al.
Publicado: (2012)

Camptothecin suppresses NRF2–ARE activity and sensitises hepatocellular carcinoma cells to anticancer drugs
por: Chen, Feng, et al.
Publicado: (2017)

Correction: Camptothecin suppresses NRF2–ARE activity and sensitises hepatocellular carcinoma cells to anticancer drugs
por: Chen, Feng, et al.
Publicado: (2019)

Enhanced p62-NRF2 Feedback Loop due to Impaired Autophagic Flux Contributes to Arsenic-Induced Malignant Transformation of Human Keratinocytes
por: Wu, Xiafang, et al.
Publicado: (2019)

The Role of Reactive Oxygen Species in Arsenic Toxicity
por: Hu, Yuxin, et al.
Publicado: (2020)

Long Isoforms of NRF1 Contribute to Arsenic-Induced Antioxidant Response in Human Keratinocytes
por: Zhao, Rui, et al.
Publicado: (2011)

Oxidative Damage and Nuclear Factor Erythroid 2-Related Factor 2 Protein Expression in Normal Skin and Keloid Tissue
por: Lee, Yoon Jin, et al.
Publicado: (2015)

Quercetin Alleviates Oxidative Damage by Activating Nuclear Factor Erythroid 2-Related Factor 2 Signaling in Porcine Enterocytes
por: Jia, Hai, et al.
Publicado: (2021)

The Transcription Factor MYB37 Positively Regulates Photosynthetic Inhibition and Oxidative Damage in Arabidopsis Leaves Under Salt Stress
por: Li, Yuanyuan, et al.
Publicado: (2022)

Role of Nuclear Factor (Erythroid-Derived 2)-Like 2 Signaling for Effects of Fumaric Acid Esters on Dendritic Cells
por: Hammer, Anna, et al.
Publicado: (2017)

Low-Level Arsenic Impairs Glucose-Stimulated Insulin Secretion in Pancreatic Beta Cells: Involvement of Cellular Adaptive Response to Oxidative Stress
por: Fu, Jingqi, et al.
Publicado: (2010)

Effects of Exposure to a DNA Damaging Agent on the Hypoxia Inducible Factors in Organogenesis Stage Mouse Limbs
por: Huang, Chunwei, et al.
Publicado: (2012)

N-Acetyl Serotonin Alleviates Oxidative Damage by Activating Nuclear Factor Erythroid 2-Related Factor 2 Signaling in Porcine Enterocytes
por: Liang, Haiwei, et al.
Publicado: (2020)

Curcumin protection against ultraviolet-induced photo-damage in Hacat cells by regulating nuclear factor erythroid 2-related factor 2
por: Deng, Huiyan, et al.
Publicado: (2021)

Atorvastatin alleviates oxidative damage by activating the nuclear factor erythroid 2-related factor 2 pathway after brain ischemia in mice
por: Fan, Jingyi, et al.
Publicado: (2022)

(S)-α-Chlorohydrin Inhibits Protein Tyrosine Phosphorylation through Blocking Cyclic AMP - Protein Kinase A Pathway in Spermatozoa
por: Zhang, Hao, et al.
Publicado: (2012)

Beneficial effects of Oltipraz, nuclear factor - erythroid – 2 - related factor 2 (Nrf2), on renal damage in unilateral ureteral obstruction rat model
por: Polat, Emre Can, et al.
Publicado: (2018)

Oxymatrine inhibits the pyroptosis in rat insulinoma cells by affecting nuclear factor kappa B and nuclear factor (erythroid-derived 2)-like 2 protein/heme oxygenase-1 pathways
por: Gao, Jingying, et al.
Publicado: (2022)

Effects of Real-Ambient PM(2.5) Exposure on Lung Damage Modulated by Nrf2(−/−)
por: Ding, Hao, et al.
Publicado: (2021)

Protective effects of nuclear factor erythroid 2-related factor 2 on whole body heat stress-induced oxidative damage in the mouse testis
por: Li, Yansen, et al.
Publicado: (2013)

Propofol protects cardiomyocytes from doxorubicin-induced toxic injury by activating the nuclear factor erythroid 2-related factor 2/glutathione peroxidase 4 signaling pathways
por: Lu, Ziyun, et al.
Publicado: (2022)

Signal amplification in the KEAP1-NRF2-ARE antioxidant response pathway
por: Liu, Shengnan, et al.
Publicado: (2022)

Mathematical modeling reveals quantitative properties of KEAP1-NRF2 signaling
por: Liu, Shengnan, et al.
Publicado: (2021)

Role of Nuclear Factor Erythroid 2-Related Factor 2 in Diabetic Nephropathy
por: Cui, Wenpeng, et al.
Publicado: (2017)

Nuclear Factor Erythroid 2-Related Factor 2 in Regulating Cancer Metabolism
por: Smolková, Katarína, et al.
Publicado: (2020)

Expression levels of RUNX3 and FGFR2 in peripheral blood of severe acute pancreatitis and their clinical significance
por: Liang, Yongyong, et al.
Publicado: (2023)

Mild hypothermia in combination with minimally invasive evacuation of hematoma reduces inflammatory damage in patients via the nuclear factor-κB pathway
por: BI, YANPING, et al.
Publicado: (2014)

Sirtuin 2 Prevents Liver Steatosis and Metabolic Disorders by Deacetylation of Hepatocyte Nuclear Factor 4α
por: Ren, Huihui, et al.
Publicado: (2021)

Nuclear Factor-κB Increases Intracellular Calcium by Upregulation of Na(+)-Ca(2+) Exchanger 1 in Cerulein-Induced Acute Pancreatitis
por: Chen, Yuyang, et al.
Publicado: (2020)

The effects of nuclear factor‐kappa B in pancreatic stellate cells on inflammation and fibrosis of chronic pancreatitis
por: Wu, Nan, et al.
Publicado: (2020)

Activation of the Nuclear Factor-kappa B Signaling Pathway Damages the Epithelial Barrier in the Human Pancreatic Ductal Adenocarcinoma Cell Line HPAF-II
por: Su, Zhou, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_3ndnpv8ke03a1ofmrsae3uaeti