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Accelerated intoxication of GABAergic synapses by botulinum neurotoxin A disinhibits stem cell-derived neuron networks prior to network silencing

Botulinum neurotoxins (BoNTs) are extremely potent toxins that specifically cleave SNARE proteins in peripheral synapses, preventing neurotransmitter release. Neuronal responses to BoNT intoxication are traditionally studied by quantifying SNARE protein cleavage in vitro or monitoring physiological...

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Detalles Bibliográficos
Autores principales:	Beske, Phillip H., Scheeler, Stephen M., Adler, Michael, McNutt, Patrick M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2015
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407583/ https://www.ncbi.nlm.nih.gov/pubmed/25954159 http://dx.doi.org/10.3389/fncel.2015.00159

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