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Refining dosing by oral gavage in the dog: A protocol to harmonise welfare
INTRODUCTION: The dog is a frequently-used, non-rodent species in the safety assessment of new chemical entities. We have a scientific and ethical obligation to ensure that the best quality of data is achieved from their use. Oral gavage is a technique frequently used to deliver a compound directly...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407634/ https://www.ncbi.nlm.nih.gov/pubmed/25575806 http://dx.doi.org/10.1016/j.vascn.2014.12.007 |