Curcumin modulates cellular AP-1, NF-kB, and HPV16 E6 proteins in oral cancer

In this study, we investigated the effects of the natural antioxidant curcumin on the HPV16-positive oral carcinoma cell line 93VU147T and demonstrated that curcumin is not only a potent inhibitor for the activity of host nuclear transcription factors AP-1 and NF-kB but it also selectively suppresse...

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Detalles Bibliográficos
Autores principales: Mishra, Alok, Kumar, Rakesh, Tyagi, Abhishek, Kohaar, Indu, Hedau, Suresh, Bharti, Alok C, Sarker, Subhodeep, Dey, Dipankar, Saluja, Daman, Das, Bhudev
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cancer Intelligence 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407748/
https://www.ncbi.nlm.nih.gov/pubmed/25932049
http://dx.doi.org/10.3332/ecancer.2015.525
Descripción
Sumario:In this study, we investigated the effects of the natural antioxidant curcumin on the HPV16-positive oral carcinoma cell line 93VU147T and demonstrated that curcumin is not only a potent inhibitor for the activity of host nuclear transcription factors AP-1 and NF-kB but it also selectively suppresses transcription of the HPV16/E6 oncogene during the carcinogenic process in oral cancer cells. This study suggests a therapeutic potential of curcumin for high-risk human papilloma virus (HPV)-infected oral cancers.

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