Curcumin modulates cellular AP-1, NF-kB, and HPV16 E6 proteins in oral cancer

In this study, we investigated the effects of the natural antioxidant curcumin on the HPV16-positive oral carcinoma cell line 93VU147T and demonstrated that curcumin is not only a potent inhibitor for the activity of host nuclear transcription factors AP-1 and NF-kB but it also selectively suppresse...

Descripción completa

Detalles Bibliográficos
Autores principales: Mishra, Alok, Kumar, Rakesh, Tyagi, Abhishek, Kohaar, Indu, Hedau, Suresh, Bharti, Alok C, Sarker, Subhodeep, Dey, Dipankar, Saluja, Daman, Das, Bhudev
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cancer Intelligence 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407748/
https://www.ncbi.nlm.nih.gov/pubmed/25932049
http://dx.doi.org/10.3332/ecancer.2015.525
_version_ 1782367953256185856
author Mishra, Alok
Kumar, Rakesh
Tyagi, Abhishek
Kohaar, Indu
Hedau, Suresh
Bharti, Alok C
Sarker, Subhodeep
Dey, Dipankar
Saluja, Daman
Das, Bhudev
author_facet Mishra, Alok
Kumar, Rakesh
Tyagi, Abhishek
Kohaar, Indu
Hedau, Suresh
Bharti, Alok C
Sarker, Subhodeep
Dey, Dipankar
Saluja, Daman
Das, Bhudev
author_sort Mishra, Alok
collection PubMed
description In this study, we investigated the effects of the natural antioxidant curcumin on the HPV16-positive oral carcinoma cell line 93VU147T and demonstrated that curcumin is not only a potent inhibitor for the activity of host nuclear transcription factors AP-1 and NF-kB but it also selectively suppresses transcription of the HPV16/E6 oncogene during the carcinogenic process in oral cancer cells. This study suggests a therapeutic potential of curcumin for high-risk human papilloma virus (HPV)-infected oral cancers.
format Online
Article
Text
id pubmed-4407748
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Cancer Intelligence
record_format MEDLINE/PubMed
spelling pubmed-44077482015-04-30 Curcumin modulates cellular AP-1, NF-kB, and HPV16 E6 proteins in oral cancer Mishra, Alok Kumar, Rakesh Tyagi, Abhishek Kohaar, Indu Hedau, Suresh Bharti, Alok C Sarker, Subhodeep Dey, Dipankar Saluja, Daman Das, Bhudev Ecancermedicalscience Research In this study, we investigated the effects of the natural antioxidant curcumin on the HPV16-positive oral carcinoma cell line 93VU147T and demonstrated that curcumin is not only a potent inhibitor for the activity of host nuclear transcription factors AP-1 and NF-kB but it also selectively suppresses transcription of the HPV16/E6 oncogene during the carcinogenic process in oral cancer cells. This study suggests a therapeutic potential of curcumin for high-risk human papilloma virus (HPV)-infected oral cancers. Cancer Intelligence 2015-04-23 /pmc/articles/PMC4407748/ /pubmed/25932049 http://dx.doi.org/10.3332/ecancer.2015.525 Text en © the authors; licensee ecancermedicalscience. http://creativecommons.org/licenses/by/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Mishra, Alok
Kumar, Rakesh
Tyagi, Abhishek
Kohaar, Indu
Hedau, Suresh
Bharti, Alok C
Sarker, Subhodeep
Dey, Dipankar
Saluja, Daman
Das, Bhudev
Curcumin modulates cellular AP-1, NF-kB, and HPV16 E6 proteins in oral cancer
title Curcumin modulates cellular AP-1, NF-kB, and HPV16 E6 proteins in oral cancer
title_full Curcumin modulates cellular AP-1, NF-kB, and HPV16 E6 proteins in oral cancer
title_fullStr Curcumin modulates cellular AP-1, NF-kB, and HPV16 E6 proteins in oral cancer
title_full_unstemmed Curcumin modulates cellular AP-1, NF-kB, and HPV16 E6 proteins in oral cancer
title_short Curcumin modulates cellular AP-1, NF-kB, and HPV16 E6 proteins in oral cancer
title_sort curcumin modulates cellular ap-1, nf-kb, and hpv16 e6 proteins in oral cancer
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407748/
https://www.ncbi.nlm.nih.gov/pubmed/25932049
http://dx.doi.org/10.3332/ecancer.2015.525
work_keys_str_mv AT mishraalok curcuminmodulatescellularap1nfkbandhpv16e6proteinsinoralcancer
AT kumarrakesh curcuminmodulatescellularap1nfkbandhpv16e6proteinsinoralcancer
AT tyagiabhishek curcuminmodulatescellularap1nfkbandhpv16e6proteinsinoralcancer
AT kohaarindu curcuminmodulatescellularap1nfkbandhpv16e6proteinsinoralcancer
AT hedausuresh curcuminmodulatescellularap1nfkbandhpv16e6proteinsinoralcancer
AT bhartialokc curcuminmodulatescellularap1nfkbandhpv16e6proteinsinoralcancer
AT sarkersubhodeep curcuminmodulatescellularap1nfkbandhpv16e6proteinsinoralcancer
AT deydipankar curcuminmodulatescellularap1nfkbandhpv16e6proteinsinoralcancer
AT salujadaman curcuminmodulatescellularap1nfkbandhpv16e6proteinsinoralcancer
AT dasbhudev curcuminmodulatescellularap1nfkbandhpv16e6proteinsinoralcancer

Ejemplares similares