FAK activity protects nucleostemin in facilitating breast cancer spheroid and tumor growth

INTRODUCTION: Focal adhesion kinase (FAK) controls cell growth and survival downstream of integrin-matrix receptors. Upon adhesion loss or FAK inhibition, FAK can translocate to the nucleus. The nucleolus is a non-membrane nuclear structure that regulates ribosome biogenesis and cell proliferation....

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Detalles Bibliográficos
Autores principales: Tancioni, Isabelle, Miller, Nichol LG, Uryu, Sean, Lawson, Christine, Jean, Christine, Chen, Xiao Lei, Kleinschmidt, Elizabeth G, Schlaepfer, David D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407832/
https://www.ncbi.nlm.nih.gov/pubmed/25880415
http://dx.doi.org/10.1186/s13058-015-0551-x

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