Metformin and Rapamycin Reduce Pancreatic Cancer Growth in Obese Prediabetic Mice by Distinct MicroRNA-Regulated Mechanisms

Metformin treatment is associated with a decreased risk and better prognosis of pancreatic cancer (PC) in patients with type 2 diabetes, but the mechanism of metformin’s PC growth inhibition in the context of a prediabetic state is unknown. We used a Panc02 pancreatic tumor cell transplant model in...

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Detalles Bibliográficos
Autores principales: Cifarelli, Vincenza, Lashinger, Laura M., Devlin, Kaylyn L., Dunlap, Sarah M., Huang, Jennifer, Kaaks, Rudolf, Pollak, Michael N., Hursting, Stephen D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2015
Materias:
Obesity Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407853/
https://www.ncbi.nlm.nih.gov/pubmed/25576058
http://dx.doi.org/10.2337/db14-1132

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407853/
https://www.ncbi.nlm.nih.gov/pubmed/25576058
http://dx.doi.org/10.2337/db14-1132

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