Genetic Variants Associated With Quantitative Glucose Homeostasis Traits Translate to Type 2 Diabetes in Mexican Americans: The GUARDIAN (Genetics Underlying Diabetes in Hispanics) Consortium

Insulin sensitivity, insulin secretion, insulin clearance, and glucose effectiveness exhibit strong genetic components, although few studies have examined their genetic architecture or influence on type 2 diabetes (T2D) risk. We hypothesized that loci affecting variation in these quantitative traits...

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Detalles Bibliográficos
Autores principales: Palmer, Nicholette D., Goodarzi, Mark O., Langefeld, Carl D., Wang, Nan, Guo, Xiuqing, Taylor, Kent D., Fingerlin, Tasha E., Norris, Jill M., Buchanan, Thomas A., Xiang, Anny H., Haritunians, Talin, Ziegler, Julie T., Williams, Adrienne H., Stefanovski, Darko, Cui, Jinrui, Mackay, Adrienne W., Henkin, Leora F., Bergman, Richard N., Gao, Xiaoyi, Gauderman, James, Varma, Rohit, Hanis, Craig L., Cox, Nancy J., Highland, Heather M., Below, Jennifer E., Williams, Amy L., Burtt, Noel P., Aguilar-Salinas, Carlos A., Huerta-Chagoya, Alicia, Gonzalez-Villalpando, Clicerio, Orozco, Lorena, Haiman, Christopher A., Tsai, Michael Y., Johnson, W. Craig, Yao, Jie, Rasmussen-Torvik, Laura, Pankow, James, Snively, Beverly, Jackson, Rebecca D., Liu, Simin, Nadler, Jerry L., Kandeel, Fouad, Chen, Yii-Der I., Bowden, Donald W., Rich, Stephen S., Raffel, Leslie J., Rotter, Jerome I., Watanabe, Richard M., Wagenknecht, Lynne E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2015
Materias:
Genetics/Genomes/Proteomics/Metabolomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407862/
https://www.ncbi.nlm.nih.gov/pubmed/25524916
http://dx.doi.org/10.2337/db14-0732

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