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Systematic Profiling of Poly(A)+ Transcripts Modulated by Core 3’ End Processing and Splicing Factors Reveals Regulatory Rules of Alternative Cleavage and Polyadenylation

Alternative cleavage and polyadenylation (APA) results in mRNA isoforms containing different 3’ untranslated regions (3’UTRs) and/or coding sequences. How core cleavage/polyadenylation (C/P) factors regulate APA is not well understood. Using siRNA knockdown coupled with deep sequencing, we found tha...

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Detalles Bibliográficos
Autores principales:	Li, Wencheng, You, Bei, Hoque, Mainul, Zheng, Dinghai, Luo, Wenting, Ji, Zhe, Park, Ji Yeon, Gunderson, Samuel I., Kalsotra, Auinash, Manley, James L., Tian, Bin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407891/ https://www.ncbi.nlm.nih.gov/pubmed/25906188 http://dx.doi.org/10.1371/journal.pgen.1005166

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