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MEASURING COGNITIVE FUNCTION IN MDD: EMERGING ASSESSMENT TOOLS

Cognitive impairment is emerging as an important therapeutic target in patients with psychiatric illnesses, including major depressive disorder (MDD). The objective of this general overview is to briefly review the evidence for cognitive impairment in MDD and to summarize a representative sample of...

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Detalles Bibliográficos
Autores principales: Russo, Manuela, Mahon, Katie, Burdick, Katherine E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407945/
https://www.ncbi.nlm.nih.gov/pubmed/25421437
http://dx.doi.org/10.1002/da.22297
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author Russo, Manuela
Mahon, Katie
Burdick, Katherine E
author_facet Russo, Manuela
Mahon, Katie
Burdick, Katherine E
author_sort Russo, Manuela
collection PubMed
description Cognitive impairment is emerging as an important therapeutic target in patients with psychiatric illnesses, including major depressive disorder (MDD). The objective of this general overview is to briefly review the evidence for cognitive impairment in MDD and to summarize a representative sample of cognitive assessment tools currently available to assess cognitive function in depressed patients. Study results in MDD patients with cognitive dysfunction are somewhat inconsistent, likely due to the heterogeneity of the disorder as well as the use of diverse assessment tools. Measuring cognitive changes in this population is challenging. Cognitive symptoms are typically less severe than in patients with schizophrenia and bipolar disorder, requiring greater sensitivity than afforded by existing tools. Preliminary evidence suggests antidepressant treatments may improve cognitive functioning as a direct result of ameliorating depressive symptoms; however, any procognitive effects have not been elucidated. To evaluate antidepressant efficacy in MDD patients with cognitive dysfunction, a standardized cognitive battery for use in clinical trials is essential.
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spelling pubmed-44079452015-04-27 MEASURING COGNITIVE FUNCTION IN MDD: EMERGING ASSESSMENT TOOLS Russo, Manuela Mahon, Katie Burdick, Katherine E Depress Anxiety Review Cognitive impairment is emerging as an important therapeutic target in patients with psychiatric illnesses, including major depressive disorder (MDD). The objective of this general overview is to briefly review the evidence for cognitive impairment in MDD and to summarize a representative sample of cognitive assessment tools currently available to assess cognitive function in depressed patients. Study results in MDD patients with cognitive dysfunction are somewhat inconsistent, likely due to the heterogeneity of the disorder as well as the use of diverse assessment tools. Measuring cognitive changes in this population is challenging. Cognitive symptoms are typically less severe than in patients with schizophrenia and bipolar disorder, requiring greater sensitivity than afforded by existing tools. Preliminary evidence suggests antidepressant treatments may improve cognitive functioning as a direct result of ameliorating depressive symptoms; however, any procognitive effects have not been elucidated. To evaluate antidepressant efficacy in MDD patients with cognitive dysfunction, a standardized cognitive battery for use in clinical trials is essential. Blackwell Publishing Ltd 2015-04 2014-11-24 /pmc/articles/PMC4407945/ /pubmed/25421437 http://dx.doi.org/10.1002/da.22297 Text en © 2014 The Authors. Depression and Anxiety published by Wiley Periodicals, Inc. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Review
Russo, Manuela
Mahon, Katie
Burdick, Katherine E
MEASURING COGNITIVE FUNCTION IN MDD: EMERGING ASSESSMENT TOOLS
title MEASURING COGNITIVE FUNCTION IN MDD: EMERGING ASSESSMENT TOOLS
title_full MEASURING COGNITIVE FUNCTION IN MDD: EMERGING ASSESSMENT TOOLS
title_fullStr MEASURING COGNITIVE FUNCTION IN MDD: EMERGING ASSESSMENT TOOLS
title_full_unstemmed MEASURING COGNITIVE FUNCTION IN MDD: EMERGING ASSESSMENT TOOLS
title_short MEASURING COGNITIVE FUNCTION IN MDD: EMERGING ASSESSMENT TOOLS
title_sort measuring cognitive function in mdd: emerging assessment tools
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407945/
https://www.ncbi.nlm.nih.gov/pubmed/25421437
http://dx.doi.org/10.1002/da.22297
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