Prediction of CD8(+) Epitopes in Leishmania braziliensis Proteins Using EPIBOT: In Silico Search and In Vivo Validation

BACKGROUND: Leishmaniasis is caused by intracellular Leishmania parasites that induce a T-cell mediated response associated with recognition of CD4(+) and CD8(+) T cell Line 1Lineepitopes. Identification of CD8(+) antigenic determinants is crucial for vaccine and therapy development. Herein, we deve...

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Detalles Bibliográficos
Autores principales: Duarte, Angelo, Queiroz, Artur T. L., Tosta, Rafael, Carvalho, Augusto M., Barbosa, Carlos Henrique, Bellio, Maria, de Oliveira, Camila I., Barral-Netto, Manoel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407964/
https://www.ncbi.nlm.nih.gov/pubmed/25905908
http://dx.doi.org/10.1371/journal.pone.0124786

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