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Synthesis of Morphinan Alkaloids in Saccharomyces cerevisiae

Morphinan alkaloids are the most powerful narcotic analgesics currently used to treat moderate to severe and chronic pain. The feasibility of morphinan synthesis in recombinant Saccharomyces cerevisiae starting from the precursor (R,S)-norlaudanosoline was investigated. Chiral analysis of the reticu...

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Detalles Bibliográficos
Autores principales:	Fossati, Elena, Narcross, Lauren, Ekins, Andrew, Falgueyret, Jean-Pierre, Martin, Vincent J. J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4408053/ https://www.ncbi.nlm.nih.gov/pubmed/25905794 http://dx.doi.org/10.1371/journal.pone.0124459

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