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DnaK as Antibiotic Target: Hot Spot Residues Analysis for Differential Inhibition of the Bacterial Protein in Comparison with the Human HSP70

DnaK, the bacterial homolog of human Hsp70, plays an important role in pathogens survival under stress conditions, like antibiotic therapies. This chaperone sequesters protein aggregates accumulated in bacteria during antibiotic treatment reducing the effect of the cure. Although different classes o...

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Detalles Bibliográficos
Autores principales:	Chiappori, Federica, Fumian, Marco, Milanesi, Luciano, Merelli, Ivan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4408060/ https://www.ncbi.nlm.nih.gov/pubmed/25905464 http://dx.doi.org/10.1371/journal.pone.0124563

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