Common Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Epitopes Mediate Multiple Routes for Internalization and Function

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a soluble protein that directs membrane-bound receptors to lysosomes for degradation. In the most studied example of this, PCSK9 binding leads to the degradation of low density lipoprotein receptor (LDLR), significantly affecting circulating L...

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Detalles Bibliográficos
Autores principales: DeVay, Rachel M., Yamamoto, Lynn, Shelton, David L., Liang, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4408062/
https://www.ncbi.nlm.nih.gov/pubmed/25905719
http://dx.doi.org/10.1371/journal.pone.0125127

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