Cargando…

FcRn Rescues Recombinant Factor VIII Fc Fusion Protein from a VWF Independent FVIII Clearance Pathway in Mouse Hepatocytes

We recently developed a longer lasting recombinant factor VIII-Fc fusion protein, rFVIIIFc, to extend the half-life of replacement FVIII for the treatment of people with hemophilia A. In order to elucidate the biological mechanism for the elongated half-life of rFVIIIFc at a cellular level we deline...

Descripción completa

Detalles Bibliográficos
Autores principales:	van der Flier, Arjan, Liu, Zhan, Tan, Siyuan, Chen, Kai, Drager, Douglas, Liu, Tongyao, Patarroyo-White, Susannah, Jiang, Haiyan, Light, David R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4408089/ https://www.ncbi.nlm.nih.gov/pubmed/25905473 http://dx.doi.org/10.1371/journal.pone.0124930

Ejemplares similares

Characterization of the Rabbit Neonatal Fc Receptor (FcRn) and Analyzing the Immunophenotype of the Transgenic Rabbits That Overexpresses FcRn
por: Catunda Lemos, Ana Paula, et al.
Publicado: (2012)

The Neonatal Fc Receptor (FcRn): A Misnomer?
por: Pyzik, Michal, et al.
Publicado: (2019)

The neonatal Fc receptor in cancer FcRn in cancer
por: Cadena Castaneda, Diana, et al.
Publicado: (2020)

The Role of FcRn in Antigen Presentation
por: Baker, Kristi, et al.
Publicado: (2014)

Roles of FcRn in Antigen-Presenting Cells during Autoimmunity and a Clinical Evaluation of Efgartigimod as an FcRn Blocker
por: Zhou, Yihan, et al.
Publicado: (2023)

FcRn is mother’s milk to allergen tolerance
por: Lambrecht, Bart N.
Publicado: (2018)

In Translation: FcRn across the Therapeutic Spectrum
por: Qi, Timothy, et al.
Publicado: (2021)

Megalin Orchestrates FcRn Endocytosis and Trafficking
por: Dahlke, Eileen, et al.
Publicado: (2022)

Selection of bispecific antibodies with optimal developability using FcRn‑Ph‑HPLC as an optimized FcRn affinity chromatography method
por: Müller, Thomas, et al.
Publicado: (2023)

FcRn Overexpression Expands Diversity of the Humoral Immune Response in bFcRn Transgenic Mice
por: Szikora, Bence, et al.
Publicado: (2020)

FcRN receptor antagonists in the management of myasthenia gravis
por: Bhandari, Vinaya, et al.
Publicado: (2023)

The importance of FcRn in neuro-immunotherapies: From IgG catabolism, FCGRT gene polymorphisms, IVIg dosing and efficiency to specific FcRn inhibitors
por: Dalakas, Marinos C., et al.
Publicado: (2021)

Pharmacokinetic Models for FcRn-Mediated IgG Disposition
por: Xiao, Jim J.
Publicado: (2012)

Cell surface dynamics and cellular distribution of endogenous FcRn
por: D’Hooghe, Lena, et al.
Publicado: (2017)

Targeting FcRn for immunomodulation: Benefits, risks, and practical considerations
por: Peter, Hans-Hartmut, et al.
Publicado: (2020)

Human IgE does not bind to human FcRn
por: Brinkhaus, Maximilian, et al.
Publicado: (2022)

The Fab region of IgG impairs the internalization pathway of FcRn upon Fc engagement
por: Brinkhaus, Maximilian, et al.
Publicado: (2022)

Harnessing Fc/FcRn Affinity Data from Patents with Different Machine Learning Methods
por: Dumet, Christophe, et al.
Publicado: (2023)

FcRn receptor-mediated pharmacokinetics of therapeutic IgG in the eye
por: Kim, Hyuncheol, et al.
Publicado: (2009)

Abundant Intracellular IgG in Enterocytes and Endoderm Lacking FcRn
por: Mohanty, Sudhasri, et al.
Publicado: (2013)

Response to “The Role of FcRn in the Pharmacokinetics of Biologics in Patients with Multiple Myeloma”
por: Xu, Xu Steven, et al.
Publicado: (2017)

FcRn Expression in Wildtype Mice, Transgenic Mice, and in Human Tissues
por: Li, Tommy, et al.
Publicado: (2018)

Human FcRn Tissue Expression Profile and Half-Life in PBMCs
por: Fan, Yao-Yun, et al.
Publicado: (2019)

FcRn inhibitors: a novel option for the treatment of myasthenia gravis
por: Zhu, Li-Na, et al.
Publicado: (2023)

Characterization of the interactions of rabbit neonatal Fc receptor (FcRn) with rabbit and human IgG isotypes
por: Szikora, Bence, et al.
Publicado: (2017)

The influence of antibody engineering on Fc conformation and Fc receptor binding properties: Analysis of FcRn-binding engineered antibodies and an Fc fusion protein
por: Suzuki, Takuo, et al.
Publicado: (2021)

The neonatal Fc receptor (FcRn) binds independently to both sites of the IgG homodimer with identical affinity
por: Abdiche, Yasmina Noubia, et al.
Publicado: (2015)

Treatment with anti‐neonatal Fc receptor (FcRn) antibody ameliorates experimental epidermolysis bullosa acquisita in mice
por: Kasprick, Anika, et al.
Publicado: (2020)

Podocyte-specific knockout of the neonatal Fc receptor (FcRn) results in differential protection depending on the model of glomerulonephritis
por: Dylewski, James F., et al.
Publicado: (2020)

FcRn mediated IgG transport by retinal pigment epithelium cells
por: Korthagen, Nicoline M, et al.
Publicado: (2012)

Charge-mediated influence of the antibody variable domain on FcRn-dependent pharmacokinetics
por: Schoch, Angela, et al.
Publicado: (2015)

Algorithmic multiscale analysis for the FcRn mediated regulation of antibody PK in human
por: Patsatzis, Dimitris G., et al.
Publicado: (2022)

FcRn as a Transporter for Nasal Delivery of Biologics: A Systematic Review
por: Fieux, Maxime, et al.
Publicado: (2021)

Maximizing in vivo target clearance by design of pH-dependent target binding antibodies with altered affinity to FcRn
por: Yang, Danlin, et al.
Publicado: (2017)

The Major Histocompatibility Complex–related Fc Receptor for IgG (FcRn) Binds Albumin and Prolongs Its Lifespan
por: Chaudhury, Chaity, et al.
Publicado: (2003)

Changes in complementarity-determining regions significantly alter IgG binding to the neonatal Fc receptor (FcRn) and pharmacokinetics
por: Piche-Nicholas, Nicole M., et al.
Publicado: (2017)

Pharmacokinetics of novel Fc-engineered monoclonal and multispecific antibodies in cynomolgus monkeys and humanized FcRn transgenic mouse models
por: Valente, Delphine, et al.
Publicado: (2020)

Human and Non-Human Primate Intestinal FcRn Expression and Immunoglobulin G Transcytosis
por: Hornby, Pamela J., et al.
Publicado: (2013)

Interactions of IgG1 CH2 and CH3 Domains with FcRn
por: Ying, Tianlei, et al.
Publicado: (2014)

Unraveling the Interaction between FcRn and Albumin: Opportunities for Design of Albumin-Based Therapeutics
por: Sand, Kine Marita Knudsen, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_s2a6q1otb7efavsqhd2sr2ko4a