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Memory fMRI predicts verbal memory decline after anterior temporal lobe resection

OBJECTIVE: To develop a clinically applicable memory functional MRI (fMRI) method of predicting postsurgical memory outcome in individual patients. METHODS: In this prospective cohort study, 50 patients with temporal lobe epilepsy (23 left) and 26 controls underwent an fMRI memory encoding paradigm...

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Autores principales: Sidhu, Meneka K., Stretton, Jason, Winston, Gavin P., Symms, Mark, Thompson, Pamela J., Koepp, Matthias J., Duncan, John S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4408284/
https://www.ncbi.nlm.nih.gov/pubmed/25770199
http://dx.doi.org/10.1212/WNL.0000000000001461
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author Sidhu, Meneka K.
Stretton, Jason
Winston, Gavin P.
Symms, Mark
Thompson, Pamela J.
Koepp, Matthias J.
Duncan, John S.
author_facet Sidhu, Meneka K.
Stretton, Jason
Winston, Gavin P.
Symms, Mark
Thompson, Pamela J.
Koepp, Matthias J.
Duncan, John S.
author_sort Sidhu, Meneka K.
collection PubMed
description OBJECTIVE: To develop a clinically applicable memory functional MRI (fMRI) method of predicting postsurgical memory outcome in individual patients. METHODS: In this prospective cohort study, 50 patients with temporal lobe epilepsy (23 left) and 26 controls underwent an fMRI memory encoding paradigm of words with a subsequent out-of-scanner recognition assessment. Neuropsychological assessment was performed preoperatively and 4 months after anterior temporal lobe resection, and at equal time intervals in controls. An event-related analysis was used to explore brain activations for words remembered and change in verbal memory scores 4 months after surgery was correlated with preoperative activations. Individual lateralization indices were calculated within a medial temporal and frontal region and compared with other clinical parameters (hippocampal volume, preoperative verbal memory, age at onset of epilepsy, and language lateralization) as a predictor of verbal memory outcome. RESULTS: In left temporal lobe epilepsy patients, left frontal and anterior medial temporal activations correlated significantly with greater verbal memory decline, while bilateral posterior hippocampal activation correlated with less verbal memory decline postoperatively. In a multivariate regression model, left lateralized memory lateralization index (≥0.5) within a medial temporal and frontal mask was the best predictor of verbal memory outcome after surgery in the dominant hemisphere in individual patients. Neither clinical nor functional MRI parameters predicted verbal memory decline after nondominant temporal lobe resection. CONCLUSION: We propose a clinically applicable memory fMRI paradigm to predict postoperative verbal memory decline after surgery in the language-dominant hemisphere in individual patients.
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spelling pubmed-44082842015-04-28 Memory fMRI predicts verbal memory decline after anterior temporal lobe resection Sidhu, Meneka K. Stretton, Jason Winston, Gavin P. Symms, Mark Thompson, Pamela J. Koepp, Matthias J. Duncan, John S. Neurology Article OBJECTIVE: To develop a clinically applicable memory functional MRI (fMRI) method of predicting postsurgical memory outcome in individual patients. METHODS: In this prospective cohort study, 50 patients with temporal lobe epilepsy (23 left) and 26 controls underwent an fMRI memory encoding paradigm of words with a subsequent out-of-scanner recognition assessment. Neuropsychological assessment was performed preoperatively and 4 months after anterior temporal lobe resection, and at equal time intervals in controls. An event-related analysis was used to explore brain activations for words remembered and change in verbal memory scores 4 months after surgery was correlated with preoperative activations. Individual lateralization indices were calculated within a medial temporal and frontal region and compared with other clinical parameters (hippocampal volume, preoperative verbal memory, age at onset of epilepsy, and language lateralization) as a predictor of verbal memory outcome. RESULTS: In left temporal lobe epilepsy patients, left frontal and anterior medial temporal activations correlated significantly with greater verbal memory decline, while bilateral posterior hippocampal activation correlated with less verbal memory decline postoperatively. In a multivariate regression model, left lateralized memory lateralization index (≥0.5) within a medial temporal and frontal mask was the best predictor of verbal memory outcome after surgery in the dominant hemisphere in individual patients. Neither clinical nor functional MRI parameters predicted verbal memory decline after nondominant temporal lobe resection. CONCLUSION: We propose a clinically applicable memory fMRI paradigm to predict postoperative verbal memory decline after surgery in the language-dominant hemisphere in individual patients. Lippincott Williams & Wilkins 2015-04-14 /pmc/articles/PMC4408284/ /pubmed/25770199 http://dx.doi.org/10.1212/WNL.0000000000001461 Text en © 2015 American Academy of Neurology This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Article
Sidhu, Meneka K.
Stretton, Jason
Winston, Gavin P.
Symms, Mark
Thompson, Pamela J.
Koepp, Matthias J.
Duncan, John S.
Memory fMRI predicts verbal memory decline after anterior temporal lobe resection
title Memory fMRI predicts verbal memory decline after anterior temporal lobe resection
title_full Memory fMRI predicts verbal memory decline after anterior temporal lobe resection
title_fullStr Memory fMRI predicts verbal memory decline after anterior temporal lobe resection
title_full_unstemmed Memory fMRI predicts verbal memory decline after anterior temporal lobe resection
title_short Memory fMRI predicts verbal memory decline after anterior temporal lobe resection
title_sort memory fmri predicts verbal memory decline after anterior temporal lobe resection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4408284/
https://www.ncbi.nlm.nih.gov/pubmed/25770199
http://dx.doi.org/10.1212/WNL.0000000000001461
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