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Matrix Metalloproteinases in Inflammatory Bowel Disease: An Update

Matrix metalloproteinases (MMPs) are known to be upregulated in inflammatory bowel disease (IBD) and other inflammatory conditions, but while their involvement is clear, their role in many settings has yet to be determined. Studies of the involvement of MMPs in IBD since 2006 have revealed an array...

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Detalles Bibliográficos
Autores principales: O'Sullivan, Shane, Gilmer, John F., Medina, Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4408746/
https://www.ncbi.nlm.nih.gov/pubmed/25948887
http://dx.doi.org/10.1155/2015/964131
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author O'Sullivan, Shane
Gilmer, John F.
Medina, Carlos
author_facet O'Sullivan, Shane
Gilmer, John F.
Medina, Carlos
author_sort O'Sullivan, Shane
collection PubMed
description Matrix metalloproteinases (MMPs) are known to be upregulated in inflammatory bowel disease (IBD) and other inflammatory conditions, but while their involvement is clear, their role in many settings has yet to be determined. Studies of the involvement of MMPs in IBD since 2006 have revealed an array of immune and stromal cells which release the proteases in response to inflammatory cytokines and growth factors. Through digestion of the extracellular matrix and cleavage of bioactive proteins, a huge diversity of roles have been revealed for the MMPs in IBD, where they have been shown to regulate epithelial barrier function, immune response, angiogenesis, fibrosis, and wound healing. For this reason, MMPs have been recognised as potential biomarkers for disease activity in IBD and inhibition remains a huge area of interest. This review describes new roles of MMPs in the pathophysiology of IBD and suggests future directions for the development of treatment strategies in this condition.
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spelling pubmed-44087462015-05-06 Matrix Metalloproteinases in Inflammatory Bowel Disease: An Update O'Sullivan, Shane Gilmer, John F. Medina, Carlos Mediators Inflamm Review Article Matrix metalloproteinases (MMPs) are known to be upregulated in inflammatory bowel disease (IBD) and other inflammatory conditions, but while their involvement is clear, their role in many settings has yet to be determined. Studies of the involvement of MMPs in IBD since 2006 have revealed an array of immune and stromal cells which release the proteases in response to inflammatory cytokines and growth factors. Through digestion of the extracellular matrix and cleavage of bioactive proteins, a huge diversity of roles have been revealed for the MMPs in IBD, where they have been shown to regulate epithelial barrier function, immune response, angiogenesis, fibrosis, and wound healing. For this reason, MMPs have been recognised as potential biomarkers for disease activity in IBD and inhibition remains a huge area of interest. This review describes new roles of MMPs in the pathophysiology of IBD and suggests future directions for the development of treatment strategies in this condition. Hindawi Publishing Corporation 2015 2015-04-08 /pmc/articles/PMC4408746/ /pubmed/25948887 http://dx.doi.org/10.1155/2015/964131 Text en Copyright © 2015 Shane O'Sullivan et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
O'Sullivan, Shane
Gilmer, John F.
Medina, Carlos
Matrix Metalloproteinases in Inflammatory Bowel Disease: An Update
title Matrix Metalloproteinases in Inflammatory Bowel Disease: An Update
title_full Matrix Metalloproteinases in Inflammatory Bowel Disease: An Update
title_fullStr Matrix Metalloproteinases in Inflammatory Bowel Disease: An Update
title_full_unstemmed Matrix Metalloproteinases in Inflammatory Bowel Disease: An Update
title_short Matrix Metalloproteinases in Inflammatory Bowel Disease: An Update
title_sort matrix metalloproteinases in inflammatory bowel disease: an update
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4408746/
https://www.ncbi.nlm.nih.gov/pubmed/25948887
http://dx.doi.org/10.1155/2015/964131
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