Protein-targeting strategy used to develop a selective inhibitor of the E17K point mutation in the PH Domain of Akt1

Ligands that can selectively bind to proteins with single amino acid point mutations offer the potential to detect or treat an abnormal protein in the presence of the wildtype. However, it is difficult to develop a selective ligand if the point mutation is not associated with an addressable location...

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Detalles Bibliográficos
Autores principales: Deyle, Kaycie M., Farrow, Blake, Hee, Ying Qiao, Work, Jeremy, Wong, Michelle, Lai, Bert, Umeda, Aiko, Millward, Steven W., Nag, Arundhati, Das, Samir, Heath, James R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4408887/
https://www.ncbi.nlm.nih.gov/pubmed/25901825
http://dx.doi.org/10.1038/nchem.2223

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4408887/
https://www.ncbi.nlm.nih.gov/pubmed/25901825
http://dx.doi.org/10.1038/nchem.2223

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