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Combined Influence of EGF+61G>A and TGFB+869T>C Functional Polymorphisms in Renal Cell Carcinoma Progression and Overall Survival: The Link to Plasma Circulating MiR-7 and MiR-221/222 Expression
The epidermal growth factor (EGF) is responsible for the activation of intracellular signal transducers that act on cell-cycle progression, cell motility, angiogenesis and inhibition of apoptosis. However, cells can block these effects activating opposite signaling pathways, such as the transforming...
Autores principales: | Teixeira, Ana L., Dias, Francisca, Ferreira, Marta, Gomes, Mónica, Santos, Juliana I., Lobo, Francisco, Maurício, Joaquina, Machado, José Carlos, Medeiros, Rui |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409046/ https://www.ncbi.nlm.nih.gov/pubmed/25909813 http://dx.doi.org/10.1371/journal.pone.0103258 |
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