A Maltose-Binding Protein Fusion Construct Yields a Robust Crystallography Platform for MCL1

Crystallization of a maltose-binding protein MCL1 fusion has yielded a robust crystallography platform that generated the first apo MCL1 crystal structure, as well as five ligand-bound structures. The ability to obtain fragment-bound structures advances structure-based drug design efforts that, desp...

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Detalles Bibliográficos
Autores principales: Clifton, Matthew C., Dranow, David M., Leed, Alison, Fulroth, Ben, Fairman, James W., Abendroth, Jan, Atkins, Kateri A., Wallace, Ellen, Fan, Dazhong, Xu, Guoping, Ni, Z. J., Daniels, Doug, Van Drie, John, Wei, Guo, Burgin, Alex B., Golub, Todd R., Hubbard, Brian K., Serrano-Wu, Michael H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409056/
https://www.ncbi.nlm.nih.gov/pubmed/25909780
http://dx.doi.org/10.1371/journal.pone.0125010

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