Global Spectrum of Copy Number Variations Reveals Genome Organizational Plasticity and Proposes New Migration Routes

Global spectrum of CNVs is required to catalog variations to provide a high-resolution on the dynamics of genome-organization and human migration. In this study, we performed genome-wide genotyping using high-resolution arrays and identified 44,109 CNVs from 1,715 genomes across 12 populations. The...

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Autores principales: Veerappa, Avinash M., Vishweswaraiah, Sangeetha, Lingaiah, Kusuma, Murthy, Megha, Suresh, Raviraj V., Manjegowda, Dinesh S., Ramachandra, Nallur B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409114/
https://www.ncbi.nlm.nih.gov/pubmed/25909454
http://dx.doi.org/10.1371/journal.pone.0121846
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author Veerappa, Avinash M.
Vishweswaraiah, Sangeetha
Lingaiah, Kusuma
Murthy, Megha
Suresh, Raviraj V.
Manjegowda, Dinesh S.
Ramachandra, Nallur B.
author_facet Veerappa, Avinash M.
Vishweswaraiah, Sangeetha
Lingaiah, Kusuma
Murthy, Megha
Suresh, Raviraj V.
Manjegowda, Dinesh S.
Ramachandra, Nallur B.
author_sort Veerappa, Avinash M.
collection PubMed
description Global spectrum of CNVs is required to catalog variations to provide a high-resolution on the dynamics of genome-organization and human migration. In this study, we performed genome-wide genotyping using high-resolution arrays and identified 44,109 CNVs from 1,715 genomes across 12 populations. The study unraveled the force of independent evolutionary dynamics on genome-organizational plasticity across populations. We demonstrated the use of CNV tool to study human migration and identified a second major settlement establishing new migration routes in addition to existing ones.
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spelling pubmed-44091142015-05-12 Global Spectrum of Copy Number Variations Reveals Genome Organizational Plasticity and Proposes New Migration Routes Veerappa, Avinash M. Vishweswaraiah, Sangeetha Lingaiah, Kusuma Murthy, Megha Suresh, Raviraj V. Manjegowda, Dinesh S. Ramachandra, Nallur B. PLoS One Research Article Global spectrum of CNVs is required to catalog variations to provide a high-resolution on the dynamics of genome-organization and human migration. In this study, we performed genome-wide genotyping using high-resolution arrays and identified 44,109 CNVs from 1,715 genomes across 12 populations. The study unraveled the force of independent evolutionary dynamics on genome-organizational plasticity across populations. We demonstrated the use of CNV tool to study human migration and identified a second major settlement establishing new migration routes in addition to existing ones. Public Library of Science 2015-04-24 /pmc/articles/PMC4409114/ /pubmed/25909454 http://dx.doi.org/10.1371/journal.pone.0121846 Text en © 2015 Veerappa et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Veerappa, Avinash M.
Vishweswaraiah, Sangeetha
Lingaiah, Kusuma
Murthy, Megha
Suresh, Raviraj V.
Manjegowda, Dinesh S.
Ramachandra, Nallur B.
Global Spectrum of Copy Number Variations Reveals Genome Organizational Plasticity and Proposes New Migration Routes
title Global Spectrum of Copy Number Variations Reveals Genome Organizational Plasticity and Proposes New Migration Routes
title_full Global Spectrum of Copy Number Variations Reveals Genome Organizational Plasticity and Proposes New Migration Routes
title_fullStr Global Spectrum of Copy Number Variations Reveals Genome Organizational Plasticity and Proposes New Migration Routes
title_full_unstemmed Global Spectrum of Copy Number Variations Reveals Genome Organizational Plasticity and Proposes New Migration Routes
title_short Global Spectrum of Copy Number Variations Reveals Genome Organizational Plasticity and Proposes New Migration Routes
title_sort global spectrum of copy number variations reveals genome organizational plasticity and proposes new migration routes
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409114/
https://www.ncbi.nlm.nih.gov/pubmed/25909454
http://dx.doi.org/10.1371/journal.pone.0121846
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