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High Frequency of Resistance, Lack of Clinical Benefit, and Poor Outcomes in Capreomycin Treated South African Patients with Extensively Drug-Resistant Tuberculosis

BACKGROUND: There are limited data about the epidemiology and treatment-related outcomes associated with capreomycin resistance in patients with XDR-TB. Capreomycin achieves high serum concentrations relative to MIC but whether capreomycin has therapeutic benefit despite microbiological resistance r...

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Detalles Bibliográficos
Autores principales:	Pietersen, Elize, Peter, Jonny, Streicher, Elizabeth, Sirgel, Frik, Rockwood, Neesha, Mastrapa, Barbara, Te Riele, Julian, Davids, Malika, van Helden, Paul, Warren, Robin, Dheda, Keertan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409172/ https://www.ncbi.nlm.nih.gov/pubmed/25909847 http://dx.doi.org/10.1371/journal.pone.0123655

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