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Cellular Models of Aggregation-dependent Template-directed Proteolysis to Characterize Tau Aggregation Inhibitors for Treatment of Alzheimer Disease

Alzheimer disease (AD) is a degenerative tauopathy characterized by aggregation of Tau protein through the repeat domain to form intraneuronal paired helical filaments (PHFs). We report two cell models in which we control the inherent toxicity of the core Tau fragment. These models demonstrate the p...

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Detalles Bibliográficos
Autores principales:	Harrington, Charles R., Storey, John M. D., Clunas, Scott, Harrington, Kathleen A., Horsley, David, Ishaq, Ahtsham, Kemp, Steven J., Larch, Christopher P., Marshall, Colin, Nicoll, Sarah L., Rickard, Janet E., Simpson, Michael, Sinclair, James P., Storey, Lynda J., Wischik, Claude M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2015
Materias:	Neurobiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409250/ https://www.ncbi.nlm.nih.gov/pubmed/25759392 http://dx.doi.org/10.1074/jbc.M114.616029

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