Cargando…

Coverage of the 2011 Q Fever Vaccination Campaign in the Netherlands, Using Retrospective Population-Based Prevalence Estimation of Cardiovascular Risk-Conditions for Chronic Q Fever

BACKGROUND: In 2011, a unique Q fever vaccination campaign targeted people at risk for chronic Q fever in the southeast of the Netherlands. General practitioners referred patients with defined cardiovascular risk-conditions (age >15 years). Prevalence rates of those risk-conditions were lacking,...

Descripción completa

Detalles Bibliográficos
Autores principales: Vermeer-de Bondt, Patricia E., Schoffelen, Teske, Vanrolleghem, Ann M., Isken, Leslie D., van Deuren, Marcel, Sturkenboom, Miriam C. J. M., Timen, Aura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409345/
https://www.ncbi.nlm.nih.gov/pubmed/25909712
http://dx.doi.org/10.1371/journal.pone.0123570
_version_ 1782368186105069568
author Vermeer-de Bondt, Patricia E.
Schoffelen, Teske
Vanrolleghem, Ann M.
Isken, Leslie D.
van Deuren, Marcel
Sturkenboom, Miriam C. J. M.
Timen, Aura
author_facet Vermeer-de Bondt, Patricia E.
Schoffelen, Teske
Vanrolleghem, Ann M.
Isken, Leslie D.
van Deuren, Marcel
Sturkenboom, Miriam C. J. M.
Timen, Aura
author_sort Vermeer-de Bondt, Patricia E.
collection PubMed
description BACKGROUND: In 2011, a unique Q fever vaccination campaign targeted people at risk for chronic Q fever in the southeast of the Netherlands. General practitioners referred patients with defined cardiovascular risk-conditions (age >15 years). Prevalence rates of those risk-conditions were lacking, standing in the way of adequate planning and coverage estimation. We aimed to obtain prevalence rates retrospectively in order to estimate coverage of the Q fever vaccination campaign. METHODS: With broad search terms for these predefined risk-conditions, we extracted patient-records from a large longitudinal general-practice research-database in the Netherlands (IPCI-database). After validation of these records, obtained prevalence rates (stratified for age and sex) extrapolated to the Q fever high-incidence area population, gave an approximation of the size of the targeted patient-group. Coverage calculation addressed people actually screened by a pre-vaccination Q fever skin test and serology (coverage) and patients referred by their general practitioners (adjusted-coverage) in the 2011 campaign. RESULTS: Our prevalence estimate of any risk-condition was 3.1% (lower-upper limits 2.9-3.3%). For heart valve defects, aorta aneurysm/prosthesis, congenital anomalies and endocarditis, prevalence was 2.4%, 0.6%, 0.4% and 0.1%, respectively. Estimated number of eligible people in the Q fever high-incidence area was 11,724 (10,965-12,532). With 1330 people screened for vaccination, coverage of the vaccination campaign was 11%. For referred people, the adjusted coverage was 18%. Coverage was lowest among the very-old and highest for people aged 50–70 years. CONCLUSION: The estimated coverage of the vaccination campaign was limited. This should be interpreted in the light of the complexity of this target-group with much co-morbidity, and of the vaccine that required invasive pre-vaccination screening. Calculation of prevalence rates of risk-conditions based on the IPCI-database was feasible. This procedure proved an efficient tool for future use, when prevalence estimates for policy, implementation or surveillance of subgroup-vaccination or other health-care interventions are needed.
format Online
Article
Text
id pubmed-4409345
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-44093452015-05-12 Coverage of the 2011 Q Fever Vaccination Campaign in the Netherlands, Using Retrospective Population-Based Prevalence Estimation of Cardiovascular Risk-Conditions for Chronic Q Fever Vermeer-de Bondt, Patricia E. Schoffelen, Teske Vanrolleghem, Ann M. Isken, Leslie D. van Deuren, Marcel Sturkenboom, Miriam C. J. M. Timen, Aura PLoS One Research Article BACKGROUND: In 2011, a unique Q fever vaccination campaign targeted people at risk for chronic Q fever in the southeast of the Netherlands. General practitioners referred patients with defined cardiovascular risk-conditions (age >15 years). Prevalence rates of those risk-conditions were lacking, standing in the way of adequate planning and coverage estimation. We aimed to obtain prevalence rates retrospectively in order to estimate coverage of the Q fever vaccination campaign. METHODS: With broad search terms for these predefined risk-conditions, we extracted patient-records from a large longitudinal general-practice research-database in the Netherlands (IPCI-database). After validation of these records, obtained prevalence rates (stratified for age and sex) extrapolated to the Q fever high-incidence area population, gave an approximation of the size of the targeted patient-group. Coverage calculation addressed people actually screened by a pre-vaccination Q fever skin test and serology (coverage) and patients referred by their general practitioners (adjusted-coverage) in the 2011 campaign. RESULTS: Our prevalence estimate of any risk-condition was 3.1% (lower-upper limits 2.9-3.3%). For heart valve defects, aorta aneurysm/prosthesis, congenital anomalies and endocarditis, prevalence was 2.4%, 0.6%, 0.4% and 0.1%, respectively. Estimated number of eligible people in the Q fever high-incidence area was 11,724 (10,965-12,532). With 1330 people screened for vaccination, coverage of the vaccination campaign was 11%. For referred people, the adjusted coverage was 18%. Coverage was lowest among the very-old and highest for people aged 50–70 years. CONCLUSION: The estimated coverage of the vaccination campaign was limited. This should be interpreted in the light of the complexity of this target-group with much co-morbidity, and of the vaccine that required invasive pre-vaccination screening. Calculation of prevalence rates of risk-conditions based on the IPCI-database was feasible. This procedure proved an efficient tool for future use, when prevalence estimates for policy, implementation or surveillance of subgroup-vaccination or other health-care interventions are needed. Public Library of Science 2015-04-24 /pmc/articles/PMC4409345/ /pubmed/25909712 http://dx.doi.org/10.1371/journal.pone.0123570 Text en © 2015 Vermeer-de Bondt et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Vermeer-de Bondt, Patricia E.
Schoffelen, Teske
Vanrolleghem, Ann M.
Isken, Leslie D.
van Deuren, Marcel
Sturkenboom, Miriam C. J. M.
Timen, Aura
Coverage of the 2011 Q Fever Vaccination Campaign in the Netherlands, Using Retrospective Population-Based Prevalence Estimation of Cardiovascular Risk-Conditions for Chronic Q Fever
title Coverage of the 2011 Q Fever Vaccination Campaign in the Netherlands, Using Retrospective Population-Based Prevalence Estimation of Cardiovascular Risk-Conditions for Chronic Q Fever
title_full Coverage of the 2011 Q Fever Vaccination Campaign in the Netherlands, Using Retrospective Population-Based Prevalence Estimation of Cardiovascular Risk-Conditions for Chronic Q Fever
title_fullStr Coverage of the 2011 Q Fever Vaccination Campaign in the Netherlands, Using Retrospective Population-Based Prevalence Estimation of Cardiovascular Risk-Conditions for Chronic Q Fever
title_full_unstemmed Coverage of the 2011 Q Fever Vaccination Campaign in the Netherlands, Using Retrospective Population-Based Prevalence Estimation of Cardiovascular Risk-Conditions for Chronic Q Fever
title_short Coverage of the 2011 Q Fever Vaccination Campaign in the Netherlands, Using Retrospective Population-Based Prevalence Estimation of Cardiovascular Risk-Conditions for Chronic Q Fever
title_sort coverage of the 2011 q fever vaccination campaign in the netherlands, using retrospective population-based prevalence estimation of cardiovascular risk-conditions for chronic q fever
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409345/
https://www.ncbi.nlm.nih.gov/pubmed/25909712
http://dx.doi.org/10.1371/journal.pone.0123570
work_keys_str_mv AT vermeerdebondtpatriciae coverageofthe2011qfevervaccinationcampaigninthenetherlandsusingretrospectivepopulationbasedprevalenceestimationofcardiovascularriskconditionsforchronicqfever
AT schoffelenteske coverageofthe2011qfevervaccinationcampaigninthenetherlandsusingretrospectivepopulationbasedprevalenceestimationofcardiovascularriskconditionsforchronicqfever
AT vanrolleghemannm coverageofthe2011qfevervaccinationcampaigninthenetherlandsusingretrospectivepopulationbasedprevalenceestimationofcardiovascularriskconditionsforchronicqfever
AT iskenleslied coverageofthe2011qfevervaccinationcampaigninthenetherlandsusingretrospectivepopulationbasedprevalenceestimationofcardiovascularriskconditionsforchronicqfever
AT vandeurenmarcel coverageofthe2011qfevervaccinationcampaigninthenetherlandsusingretrospectivepopulationbasedprevalenceestimationofcardiovascularriskconditionsforchronicqfever
AT sturkenboommiriamcjm coverageofthe2011qfevervaccinationcampaigninthenetherlandsusingretrospectivepopulationbasedprevalenceestimationofcardiovascularriskconditionsforchronicqfever
AT timenaura coverageofthe2011qfevervaccinationcampaigninthenetherlandsusingretrospectivepopulationbasedprevalenceestimationofcardiovascularriskconditionsforchronicqfever