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Determining the Functions of HIV-1 Tat and a Second Magnesium Ion in the CDK9/Cyclin T1 Complex: A Molecular Dynamics Simulation Study

The current paradigm of cyclin-dependent kinase (CDK) regulation based on the well-established CDK2 has been recently expanded. The determination of CDK9 crystal structures suggests the requirement of an additional regulatory protein, such as human immunodeficiency virus type 1 (HIV-1) Tat, to exert...

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Detalles Bibliográficos
Autores principales:	Jin, Hai-Xiao, Go, Mei-Lin, Yin, Peng, Qiu, Xiao-Ting, Zhu, Peng, Yan, Xiao-Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409394/ https://www.ncbi.nlm.nih.gov/pubmed/25909811 http://dx.doi.org/10.1371/journal.pone.0124673

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