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Corticolimbic catecholamines in stress: a computational model of the appraisal of controllability

Appraisal of a stressful situation and the possibility to control or avoid it is thought to involve frontal-cortical mechanisms. The precise mechanism underlying this appraisal and its translation into effective stress coping (the regulation of physiological and behavioural responses) are poorly und...

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Autores principales: Fiore, Vincenzo G., Mannella, Francesco, Mirolli, Marco, Latagliata, Emanuele Claudio, Valzania, Alessandro, Cabib, Simona, Dolan, Raymond J., Puglisi-Allegra, Stefano, Baldassarre, Gianluca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409646/
https://www.ncbi.nlm.nih.gov/pubmed/24578177
http://dx.doi.org/10.1007/s00429-014-0727-7
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author Fiore, Vincenzo G.
Mannella, Francesco
Mirolli, Marco
Latagliata, Emanuele Claudio
Valzania, Alessandro
Cabib, Simona
Dolan, Raymond J.
Puglisi-Allegra, Stefano
Baldassarre, Gianluca
author_facet Fiore, Vincenzo G.
Mannella, Francesco
Mirolli, Marco
Latagliata, Emanuele Claudio
Valzania, Alessandro
Cabib, Simona
Dolan, Raymond J.
Puglisi-Allegra, Stefano
Baldassarre, Gianluca
author_sort Fiore, Vincenzo G.
collection PubMed
description Appraisal of a stressful situation and the possibility to control or avoid it is thought to involve frontal-cortical mechanisms. The precise mechanism underlying this appraisal and its translation into effective stress coping (the regulation of physiological and behavioural responses) are poorly understood. Here, we propose a computational model which involves tuning motivational arousal to the appraised stressing condition. The model provides a causal explanation of the shift from active to passive coping strategies, i.e. from a condition characterised by high motivational arousal, required to deal with a situation appraised as stressful, to a condition characterised by emotional and motivational withdrawal, required when the stressful situation is appraised as uncontrollable/unavoidable. The model is motivated by results acquired via microdialysis recordings in rats and highlights the presence of two competing circuits dominated by different areas of the ventromedial prefrontal cortex: these are shown having opposite effects on several subcortical areas, affecting dopamine outflow in the striatum, and therefore controlling motivation. We start by reviewing published data supporting structure and functioning of the neural model and present the computational model itself with its essential neural mechanisms. Finally, we show the results of a new experiment, involving the condition of repeated inescapable stress, which validate most of the model’s predictions.
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spelling pubmed-44096462015-04-30 Corticolimbic catecholamines in stress: a computational model of the appraisal of controllability Fiore, Vincenzo G. Mannella, Francesco Mirolli, Marco Latagliata, Emanuele Claudio Valzania, Alessandro Cabib, Simona Dolan, Raymond J. Puglisi-Allegra, Stefano Baldassarre, Gianluca Brain Struct Funct Original Article Appraisal of a stressful situation and the possibility to control or avoid it is thought to involve frontal-cortical mechanisms. The precise mechanism underlying this appraisal and its translation into effective stress coping (the regulation of physiological and behavioural responses) are poorly understood. Here, we propose a computational model which involves tuning motivational arousal to the appraised stressing condition. The model provides a causal explanation of the shift from active to passive coping strategies, i.e. from a condition characterised by high motivational arousal, required to deal with a situation appraised as stressful, to a condition characterised by emotional and motivational withdrawal, required when the stressful situation is appraised as uncontrollable/unavoidable. The model is motivated by results acquired via microdialysis recordings in rats and highlights the presence of two competing circuits dominated by different areas of the ventromedial prefrontal cortex: these are shown having opposite effects on several subcortical areas, affecting dopamine outflow in the striatum, and therefore controlling motivation. We start by reviewing published data supporting structure and functioning of the neural model and present the computational model itself with its essential neural mechanisms. Finally, we show the results of a new experiment, involving the condition of repeated inescapable stress, which validate most of the model’s predictions. Springer Berlin Heidelberg 2014-02-28 2015 /pmc/articles/PMC4409646/ /pubmed/24578177 http://dx.doi.org/10.1007/s00429-014-0727-7 Text en © The Author(s) 2014 https://creativecommons.org/licenses/by/4.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Original Article
Fiore, Vincenzo G.
Mannella, Francesco
Mirolli, Marco
Latagliata, Emanuele Claudio
Valzania, Alessandro
Cabib, Simona
Dolan, Raymond J.
Puglisi-Allegra, Stefano
Baldassarre, Gianluca
Corticolimbic catecholamines in stress: a computational model of the appraisal of controllability
title Corticolimbic catecholamines in stress: a computational model of the appraisal of controllability
title_full Corticolimbic catecholamines in stress: a computational model of the appraisal of controllability
title_fullStr Corticolimbic catecholamines in stress: a computational model of the appraisal of controllability
title_full_unstemmed Corticolimbic catecholamines in stress: a computational model of the appraisal of controllability
title_short Corticolimbic catecholamines in stress: a computational model of the appraisal of controllability
title_sort corticolimbic catecholamines in stress: a computational model of the appraisal of controllability
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409646/
https://www.ncbi.nlm.nih.gov/pubmed/24578177
http://dx.doi.org/10.1007/s00429-014-0727-7
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