Characterization of Aldh2(-/-) mice as an age-related model of cognitive impairment and Alzheimer’s disease

BACKGROUND: The study of late-onset/age-related Alzheimer’s disease (AD)(sporadic AD, 95% of AD cases) has been hampered by a paucity of animal models. Oxidative stress is considered a causative factor in late onset/age-related AD, and aldehyde dehydrogenase 2 (ALDH2) is important for the catabolism...

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Detalles Bibliográficos
Autores principales: D’Souza, Yohan, Elharram, Ahmed, Soon-Shiong, Raquel, Andrew, R David, Bennett, Brian M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409701/
https://www.ncbi.nlm.nih.gov/pubmed/25910195
http://dx.doi.org/10.1186/s13041-015-0117-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409701/
https://www.ncbi.nlm.nih.gov/pubmed/25910195
http://dx.doi.org/10.1186/s13041-015-0117-y

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