Cargando…

Characterization of Aldh2(-/-) mice as an age-related model of cognitive impairment and Alzheimer’s disease

BACKGROUND: The study of late-onset/age-related Alzheimer’s disease (AD)(sporadic AD, 95% of AD cases) has been hampered by a paucity of animal models. Oxidative stress is considered a causative factor in late onset/age-related AD, and aldehyde dehydrogenase 2 (ALDH2) is important for the catabolism...

Descripción completa

Detalles Bibliográficos
Autores principales:	D’Souza, Yohan, Elharram, Ahmed, Soon-Shiong, Raquel, Andrew, R David, Bennett, Brian M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409701/ https://www.ncbi.nlm.nih.gov/pubmed/25910195 http://dx.doi.org/10.1186/s13041-015-0117-y

Ejemplares similares

A multifunctional therapeutic approach to disease modification in multiple familial mouse models and a novel sporadic model of Alzheimer’s disease
por: Luo, Jia, et al.
Publicado: (2016)

Erratum to: A multifunctional therapeutic approach to disease modification in multiple familial mouse models and a novel sporadic model of Alzheimer’s disease
por: Luo, Jia, et al.
Publicado: (2016)

Age-dependent postoperative cognitive impairment and Alzheimer-related neuropathology in mice
por: Xu, Zhipeng, et al.
Publicado: (2014)

Neuronal Calcium Imaging, Excitability, and Plasticity Changes in the Aldh2(–)/(–) Mouse Model of Sporadic Alzheimer’s Disease
por: Ghoweri, Adam O., et al.
Publicado: (2020)

Sleep fragmentation, microglial aging, and cognitive impairment in adults with and without Alzheimer’s dementia
por: Kaneshwaran, Kirusanthy, et al.
Publicado: (2019)

The neurotrophic compound J147 reverses cognitive impairment in aged Alzheimer's disease mice
por: Prior, Marguerite, et al.
Publicado: (2013)

Detection and Prediction of Mild Cognitive Impairment in Alzheimer’s Disease Mice
por: Rai, Surya Prakash, et al.
Publicado: (2020)

Genome-wide characterization of ALDH Superfamily in Brassica rapa and enhancement of stress tolerance in heterologous hosts by BrALDH7B2 expression
por: Gautam, Ranjana, et al.
Publicado: (2019)

Elevations in Serum Dickkopf-1 and Disease Progression in Community-Dwelling Older Adults With Mild Cognitive Impairment and Mild-to-Moderate Alzheimer’s Disease
por: Tay, Laura, et al.
Publicado: (2019)

Total output and switching in category fluency successfully discriminates Alzheimer's disease from Mild Cognitive Impairment, but not from frontotemporal dementia
por: Ramanan, Siddharth, et al.
Publicado: (2015)

Impact of common ALDH2 inactivating mutation and alcohol consumption on Alzheimer’s disease
por: Seike, Takuya, et al.
Publicado: (2023)

Emotional Processing in Healthy Ageing, Mild Cognitive Impairment, and Alzheimer’s Disease
por: Cárdenas, José, et al.
Publicado: (2021)

Molecular Characterization and Clinical Relevance of ALDH2 in Human Cancers
por: Ma, Bo, et al.
Publicado: (2022)

Treatment of cognitive impairment in Alzheimer's disease
por: Burns, Alistair
Publicado: (2003)

Mitochondria, Cognitive Impairment, and Alzheimer's Disease
por: Mancuso, M., et al.
Publicado: (2009)

Nutraceuticals in cognitive impairment and Alzheimer’s disease
por: Mecocci, P., et al.
Publicado: (2014)

Neurological Soft Signs in Aging, Mild Cognitive Impairment, and Alzheimer’s Disease – The Impact of Cognitive Decline and Cognitive Reserve
por: Urbanowitsch, Nadja, et al.
Publicado: (2015)

Generation and characterization of Aldh3-Cre transgenic mice as a tool for conditional gene deletion in postnatal cornea
por: Sunny, Sweetu Susan, et al.
Publicado: (2020)

BrainAGE in Mild Cognitive Impaired Patients: Predicting the Conversion to Alzheimer’s Disease
por: Gaser, Christian, et al.
Publicado: (2013)

Age-Related Eye Diseases in Individuals With Mild Cognitive Impairment and Alzheimer's Disease
por: Chua, Jacqueline, et al.
Publicado: (2022)

Cognitive Blackouts in Mild Cognitive Impairment and Alzheimer's Dementia
por: Adler, Georg, et al.
Publicado: (2018)

An immune response characterizes early Alzheimer’s disease pathology and subjective cognitive impairment in hydrocephalus biopsies
por: Huang, Wenrui, et al.
Publicado: (2021)

Multimodal Discrimination between Normal Aging, Mild Cognitive Impairment and Alzheimer’s Disease and Prediction of Cognitive Decline
por: Bauer, Corinna M., et al.
Publicado: (2018)

The Differential Role of Executive Apathy in Alzheimer’s Disease Dementia, Mild Cognitive Impairment and Healthy Cognitive Ageing
por: Mougias, Michalis, et al.
Publicado: (2023)

Evaluation of STAT3 Signaling in ALDH+ and ALDH+/CD44+/CD24− Subpopulations of Breast Cancer Cells
por: Lin, Li, et al.
Publicado: (2013)

Epigenetic mechanisms underlying cognitive impairment and Alzheimer disease hallmarks in 5XFAD mice
por: Griñán-Ferré, Christian, et al.
Publicado: (2016)

Repeated abortion in adulthood induces cognition impairment in aged mice
por: Wang, Lili, et al.
Publicado: (2018)

Tregs dysfunction aggravates postoperative cognitive impairment in aged mice
por: Zhou, Yile, et al.
Publicado: (2023)

ALDH1 Bio-activates Nifuroxazide to Eradicate ALDH(High) Melanoma-Initiating Cells
por: Sarvi, Sana, et al.
Publicado: (2018)

Quantification of cognitive impairment to characterize heterogeneity of patients at risk of developing Alzheimer's disease dementia
por: Giraldo, Diana L., et al.
Publicado: (2021)

Update on the aldehyde dehydrogenase gene (ALDH) superfamily
por: Jackson, Brian, et al.
Publicado: (2011)

Specific serum antibody binding to phosphorylated and non-phosphorylated tau in non-cognitively impaired, mildly cognitively impaired, and Alzheimer’s disease subjects: an exploratory study
por: Klaver, Andrea C., et al.
Publicado: (2017)

The Effect of the APOE Genotype on Individual BrainAGE in Normal Aging, Mild Cognitive Impairment, and Alzheimer’s Disease
por: Löwe, Luise Christine, et al.
Publicado: (2016)

Association of Neuropathological Markers in the Parietal Cortex With Antemortem Cognitive Function in Persons With Mild Cognitive Impairment and Alzheimer Disease
por: Tremblay, Cyntia, et al.
Publicado: (2017)

Editorial: Metabolic signaling dysregulation and cognitive impairments in aging and Alzheimer's disease, volume II
por: Ma, Tao, et al.
Publicado: (2023)

New strategies for Alzheimer disease and cognitive impairment
por: Maiese, Kenneth, et al.
Publicado: (2009)

Effectiveness of exercise on cognitive impairment and Alzheimer’s disease
por: Balsamo, Sandor, et al.
Publicado: (2013)

The Fornix in Mild Cognitive Impairment and Alzheimer’s Disease
por: Nowrangi, Milap A., et al.
Publicado: (2015)

Judgment in Mild Cognitive Impairment and Alzheimer's disease
por: Capucho, Patrícia Helena Figueirêdo Vale, et al.
Publicado: (2011)

Quercitrin improved cognitive impairment through inhibiting inflammation induced by microglia in Alzheimer’s disease mice
por: Wang, Lixin, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_2l02r4970aflsg2ubauveneios