Cargando…
MiR-133a is downregulated in non-small cell lung cancer: a study of clinical significance
BACKGROUND: Despite present studies which suggested miR-133a as a promising biomarker for several cancers, there still exist no articles concerning the validated clinical significance of miR-133a in non-small cell lung cancer (NSCLC). Therefore, in this study, we targeted the correlation between miR...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409717/ https://www.ncbi.nlm.nih.gov/pubmed/25903369 http://dx.doi.org/10.1186/s40001-015-0139-z |
_version_ | 1782368222420402176 |
---|---|
author | Lan, Dong Zhang, Xin He, Rongquan Tang, Ruixue Li, Ping He, Qiancheng Chen, Gang |
author_facet | Lan, Dong Zhang, Xin He, Rongquan Tang, Ruixue Li, Ping He, Qiancheng Chen, Gang |
author_sort | Lan, Dong |
collection | PubMed |
description | BACKGROUND: Despite present studies which suggested miR-133a as a promising biomarker for several cancers, there still exist no articles concerning the validated clinical significance of miR-133a in non-small cell lung cancer (NSCLC). Therefore, in this study, we targeted the correlation between miR-133a expression and clinicopathological significance in NSCLC patients. METHODS: The expression of miR-133a in 125 cases of NSCLC and their paired adjacent non-cancerous tissues was evaluated by quantitative reverse transcription polymerase chain reaction (qRT-PCR). Meanwhile, the relationship between miR-133a expression and several clinicopathological parameters and patient survival was analyzed. RESULTS: The relative level of miR-133a was 2.0108 ± 1.3334 in NSCLC tissues, significantly lower than that of the adjacent non-cancerous lung tissues (3.6430 ± 2.2625, P = 0.019). The area under curve (AUC) of low expression of miR-133a to diagnose NSCLC was 0.760 (95% CI: 0.702 ~ 0.819, P < 0.001). MiR-133a expression was negatively correlated to lymphatic metastasis (r = −0.182, P = 0.042), tumor size (r = −0.253, P = 0.04), clinical TNM stages (r = −0.154, P = 0.087), and EGFR protein expression (r = −0.612, P < 0.001). CONCLUSIONS: MiR-133a serves as a tumor-suppressive miRNA in human NSCLC, and its downregulation suggests deterioration in NSCLC patients. |
format | Online Article Text |
id | pubmed-4409717 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-44097172015-04-26 MiR-133a is downregulated in non-small cell lung cancer: a study of clinical significance Lan, Dong Zhang, Xin He, Rongquan Tang, Ruixue Li, Ping He, Qiancheng Chen, Gang Eur J Med Res Research BACKGROUND: Despite present studies which suggested miR-133a as a promising biomarker for several cancers, there still exist no articles concerning the validated clinical significance of miR-133a in non-small cell lung cancer (NSCLC). Therefore, in this study, we targeted the correlation between miR-133a expression and clinicopathological significance in NSCLC patients. METHODS: The expression of miR-133a in 125 cases of NSCLC and their paired adjacent non-cancerous tissues was evaluated by quantitative reverse transcription polymerase chain reaction (qRT-PCR). Meanwhile, the relationship between miR-133a expression and several clinicopathological parameters and patient survival was analyzed. RESULTS: The relative level of miR-133a was 2.0108 ± 1.3334 in NSCLC tissues, significantly lower than that of the adjacent non-cancerous lung tissues (3.6430 ± 2.2625, P = 0.019). The area under curve (AUC) of low expression of miR-133a to diagnose NSCLC was 0.760 (95% CI: 0.702 ~ 0.819, P < 0.001). MiR-133a expression was negatively correlated to lymphatic metastasis (r = −0.182, P = 0.042), tumor size (r = −0.253, P = 0.04), clinical TNM stages (r = −0.154, P = 0.087), and EGFR protein expression (r = −0.612, P < 0.001). CONCLUSIONS: MiR-133a serves as a tumor-suppressive miRNA in human NSCLC, and its downregulation suggests deterioration in NSCLC patients. BioMed Central 2015-04-23 /pmc/articles/PMC4409717/ /pubmed/25903369 http://dx.doi.org/10.1186/s40001-015-0139-z Text en © Lan et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Lan, Dong Zhang, Xin He, Rongquan Tang, Ruixue Li, Ping He, Qiancheng Chen, Gang MiR-133a is downregulated in non-small cell lung cancer: a study of clinical significance |
title | MiR-133a is downregulated in non-small cell lung cancer: a study of clinical significance |
title_full | MiR-133a is downregulated in non-small cell lung cancer: a study of clinical significance |
title_fullStr | MiR-133a is downregulated in non-small cell lung cancer: a study of clinical significance |
title_full_unstemmed | MiR-133a is downregulated in non-small cell lung cancer: a study of clinical significance |
title_short | MiR-133a is downregulated in non-small cell lung cancer: a study of clinical significance |
title_sort | mir-133a is downregulated in non-small cell lung cancer: a study of clinical significance |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409717/ https://www.ncbi.nlm.nih.gov/pubmed/25903369 http://dx.doi.org/10.1186/s40001-015-0139-z |
work_keys_str_mv | AT landong mir133aisdownregulatedinnonsmallcelllungcancerastudyofclinicalsignificance AT zhangxin mir133aisdownregulatedinnonsmallcelllungcancerastudyofclinicalsignificance AT herongquan mir133aisdownregulatedinnonsmallcelllungcancerastudyofclinicalsignificance AT tangruixue mir133aisdownregulatedinnonsmallcelllungcancerastudyofclinicalsignificance AT liping mir133aisdownregulatedinnonsmallcelllungcancerastudyofclinicalsignificance AT heqiancheng mir133aisdownregulatedinnonsmallcelllungcancerastudyofclinicalsignificance AT chengang mir133aisdownregulatedinnonsmallcelllungcancerastudyofclinicalsignificance |