Human severe sepsis cytokine mixture increases β2-integrin-dependent polymorphonuclear leukocyte adhesion to cerebral microvascular endothelial cells in vitro

INTRODUCTION: Sepsis-associated encephalopathy (SAE) is a state of acute brain dysfunction in response to a systemic infection. We propose that systemic inflammation during sepsis causes increased adhesion of leukocytes to the brain microvasculature, resulting in blood-brain barrier dysfunction. Thu...

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Detalles Bibliográficos
Autores principales: Blom, Chris, Deller, Brittany L, Fraser, Douglas D, Patterson, Eric K, Martin, Claudio M, Young, Bryan, Liaw, Patricia C, Yazdan-Ashoori, Payam, Ortiz, Angelica, Webb, Brian, Kilmer, Greg, Carter, David E, Cepinskas, Gediminas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409718/
https://www.ncbi.nlm.nih.gov/pubmed/25882865
http://dx.doi.org/10.1186/s13054-015-0883-z

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