Chemoresistance is associated with increased cytoprotective autophagy and diminished apoptosis in bladder cancer cells treated with the BH3 mimetic (−)-Gossypol (AT-101)

BACKGROUND: Acquired resistance to standard chemotherapy causes treatment failure in patients with metastatic bladder cancer. Overexpression of pro-survival Bcl-2 family proteins has been associated with a poor chemotherapeutic response, suggesting that Bcl-2-targeted therapy may be a feasible strat...

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Detalles Bibliográficos
Autores principales: Mani, Jens, Vallo, Stefan, Rakel, Stefanie, Antonietti, Patrick, Gessler, Florian, Blaheta, Roman, Bartsch, Georg, Michaelis, Martin, Cinatl, Jindrich, Haferkamp, Axel, Kögel, Donat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409725/
https://www.ncbi.nlm.nih.gov/pubmed/25885284
http://dx.doi.org/10.1186/s12885-015-1239-4

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