Synthesis of a 2''-Deoxy-β-GalCer

Structural studies of ternary complexes of CD1d/glycosyl ceramides/iNKT cells and CD1d/sulfatide/sulfatide reactive Type II NKT cells have shown how the polar moieties on the glycolipids interact with both the antigen presenting protein (CD1d) and the T cell receptors. However, these structures alon...

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Autores principales: Thakur, Meena S., Khurana, Archana, Kronenberg, Mitchell, Howell, Amy R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409828/
https://www.ncbi.nlm.nih.gov/pubmed/25014535
http://dx.doi.org/10.3390/molecules190710090
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author Thakur, Meena S.
Khurana, Archana
Kronenberg, Mitchell
Howell, Amy R.
author_facet Thakur, Meena S.
Khurana, Archana
Kronenberg, Mitchell
Howell, Amy R.
author_sort Thakur, Meena S.
collection PubMed
description Structural studies of ternary complexes of CD1d/glycosyl ceramides/iNKT cells and CD1d/sulfatide/sulfatide reactive Type II NKT cells have shown how the polar moieties on the glycolipids interact with both the antigen presenting protein (CD1d) and the T cell receptors. However, these structures alone do not reveal the relative importance of these interactions. This study focuses on the synthesis of the previously unknown 2''-deoxy-β-galactosyl ceramide 2. This glycolipid is also evaluated for its ability to stimulate iNKT cells and sulfatide-reactive Type II NKT cells.
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spelling pubmed-44098282015-07-10 Synthesis of a 2''-Deoxy-β-GalCer Thakur, Meena S. Khurana, Archana Kronenberg, Mitchell Howell, Amy R. Molecules Article Structural studies of ternary complexes of CD1d/glycosyl ceramides/iNKT cells and CD1d/sulfatide/sulfatide reactive Type II NKT cells have shown how the polar moieties on the glycolipids interact with both the antigen presenting protein (CD1d) and the T cell receptors. However, these structures alone do not reveal the relative importance of these interactions. This study focuses on the synthesis of the previously unknown 2''-deoxy-β-galactosyl ceramide 2. This glycolipid is also evaluated for its ability to stimulate iNKT cells and sulfatide-reactive Type II NKT cells. MDPI 2014-07-10 /pmc/articles/PMC4409828/ /pubmed/25014535 http://dx.doi.org/10.3390/molecules190710090 Text en © 2014 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Thakur, Meena S.
Khurana, Archana
Kronenberg, Mitchell
Howell, Amy R.
Synthesis of a 2''-Deoxy-β-GalCer
title Synthesis of a 2''-Deoxy-β-GalCer
title_full Synthesis of a 2''-Deoxy-β-GalCer
title_fullStr Synthesis of a 2''-Deoxy-β-GalCer
title_full_unstemmed Synthesis of a 2''-Deoxy-β-GalCer
title_short Synthesis of a 2''-Deoxy-β-GalCer
title_sort synthesis of a 2''-deoxy-β-galcer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409828/
https://www.ncbi.nlm.nih.gov/pubmed/25014535
http://dx.doi.org/10.3390/molecules190710090
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