Cargando…
Accuracy of two continuous glucose monitoring systems: a head-to-head comparison under clinical research centre and daily life conditions
AIMS: To assess the accuracy and reliability of the two most widely used continuous glucose monitoring (CGM) systems. METHODS: We studied the Dexcom®G4 Platinum (DG4P; Dexcom, San Diego, CA, USA) and Medtronic Paradigm Veo Enlite system (ENL; Medtronic, Northridge, CA, USA) CGM systems, in 24 patien...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409843/ https://www.ncbi.nlm.nih.gov/pubmed/25132320 http://dx.doi.org/10.1111/dom.12378 |
_version_ | 1782368247690035200 |
---|---|
author | Kropff, J Bruttomesso, D Doll, W Farret, A Galasso, S Luijf, Y M Mader, J K Place, J Boscari, F Pieber, T R Renard, E DeVries, J H |
author_facet | Kropff, J Bruttomesso, D Doll, W Farret, A Galasso, S Luijf, Y M Mader, J K Place, J Boscari, F Pieber, T R Renard, E DeVries, J H |
author_sort | Kropff, J |
collection | PubMed |
description | AIMS: To assess the accuracy and reliability of the two most widely used continuous glucose monitoring (CGM) systems. METHODS: We studied the Dexcom®G4 Platinum (DG4P; Dexcom, San Diego, CA, USA) and Medtronic Paradigm Veo Enlite system (ENL; Medtronic, Northridge, CA, USA) CGM systems, in 24 patients with type 1 diabetes. The CGM systems were tested during 6-day home use and a nested 6-h clinical research centre (CRC) visit. During the CRC visit, frequent venous blood glucose samples were used as reference while patients received a meal with an increased insulin bolus to induce an aggravated postprandial glucose nadir. At home, patients performed at least six reference capillary blood measurements per day. A Wilcoxon signed-rank test was performed using all data points ≥15 min apart. RESULTS: The overall mean absolute relative difference (MARD) value [standard deviation (s.d.)] measured at the CRC was 13.6 (11.0)% for the DG4P and 16.6 (13.5)% for the ENL [p < 0.0002, confidence interval of difference (CI Δ) 1.7–4.3%, n = 530]. The overall MARD assessed at home was 12.2 (12.0)% for the DG4P and 19.9 (20.5)% for the ENL (p < 0.0001, CI Δ = 5.8–8.7%, n = 839). During the CRC visit, the MARD in the hypoglycaemic range [≤3.9 mmol/l (70 mg/dl)], was 17.6 (12.2)% for the DG4P and 24.6 (18.8)% for the ENL (p = 0.005, CI Δ 3.1–10.7%, n = 117). Both sensors showed higher MARD values during hypoglycaemia than during euglycaemia [3.9–10 mmol/l (70–180 mg/dl)]: for the DG4P 17.6 versus 13.0% and for the ENL 24.6 versus 14.2%. CONCLUSIONS: During circumstances of intended use, including both a CRC and home phase, the ENL was noticeably less accurate than the DG4P sensor. Both sensors showed lower accuracy in the hypoglycaemic range. The DG4P was less affected by this negative effect of hypoglycaemia on sensor accuracy than was the ENL. |
format | Online Article Text |
id | pubmed-4409843 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-44098432015-04-29 Accuracy of two continuous glucose monitoring systems: a head-to-head comparison under clinical research centre and daily life conditions Kropff, J Bruttomesso, D Doll, W Farret, A Galasso, S Luijf, Y M Mader, J K Place, J Boscari, F Pieber, T R Renard, E DeVries, J H Diabetes Obes Metab Original Articles AIMS: To assess the accuracy and reliability of the two most widely used continuous glucose monitoring (CGM) systems. METHODS: We studied the Dexcom®G4 Platinum (DG4P; Dexcom, San Diego, CA, USA) and Medtronic Paradigm Veo Enlite system (ENL; Medtronic, Northridge, CA, USA) CGM systems, in 24 patients with type 1 diabetes. The CGM systems were tested during 6-day home use and a nested 6-h clinical research centre (CRC) visit. During the CRC visit, frequent venous blood glucose samples were used as reference while patients received a meal with an increased insulin bolus to induce an aggravated postprandial glucose nadir. At home, patients performed at least six reference capillary blood measurements per day. A Wilcoxon signed-rank test was performed using all data points ≥15 min apart. RESULTS: The overall mean absolute relative difference (MARD) value [standard deviation (s.d.)] measured at the CRC was 13.6 (11.0)% for the DG4P and 16.6 (13.5)% for the ENL [p < 0.0002, confidence interval of difference (CI Δ) 1.7–4.3%, n = 530]. The overall MARD assessed at home was 12.2 (12.0)% for the DG4P and 19.9 (20.5)% for the ENL (p < 0.0001, CI Δ = 5.8–8.7%, n = 839). During the CRC visit, the MARD in the hypoglycaemic range [≤3.9 mmol/l (70 mg/dl)], was 17.6 (12.2)% for the DG4P and 24.6 (18.8)% for the ENL (p = 0.005, CI Δ 3.1–10.7%, n = 117). Both sensors showed higher MARD values during hypoglycaemia than during euglycaemia [3.9–10 mmol/l (70–180 mg/dl)]: for the DG4P 17.6 versus 13.0% and for the ENL 24.6 versus 14.2%. CONCLUSIONS: During circumstances of intended use, including both a CRC and home phase, the ENL was noticeably less accurate than the DG4P sensor. Both sensors showed lower accuracy in the hypoglycaemic range. The DG4P was less affected by this negative effect of hypoglycaemia on sensor accuracy than was the ENL. Blackwell Publishing Ltd 2015-04 2014-09-10 /pmc/articles/PMC4409843/ /pubmed/25132320 http://dx.doi.org/10.1111/dom.12378 Text en © 2014 The Authors. Diabetes, Obesity and Metabolism published by John Wiley & Sons Ltd. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Original Articles Kropff, J Bruttomesso, D Doll, W Farret, A Galasso, S Luijf, Y M Mader, J K Place, J Boscari, F Pieber, T R Renard, E DeVries, J H Accuracy of two continuous glucose monitoring systems: a head-to-head comparison under clinical research centre and daily life conditions |
title | Accuracy of two continuous glucose monitoring systems: a head-to-head comparison under clinical research centre and daily life conditions |
title_full | Accuracy of two continuous glucose monitoring systems: a head-to-head comparison under clinical research centre and daily life conditions |
title_fullStr | Accuracy of two continuous glucose monitoring systems: a head-to-head comparison under clinical research centre and daily life conditions |
title_full_unstemmed | Accuracy of two continuous glucose monitoring systems: a head-to-head comparison under clinical research centre and daily life conditions |
title_short | Accuracy of two continuous glucose monitoring systems: a head-to-head comparison under clinical research centre and daily life conditions |
title_sort | accuracy of two continuous glucose monitoring systems: a head-to-head comparison under clinical research centre and daily life conditions |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409843/ https://www.ncbi.nlm.nih.gov/pubmed/25132320 http://dx.doi.org/10.1111/dom.12378 |
work_keys_str_mv | AT kropffj accuracyoftwocontinuousglucosemonitoringsystemsaheadtoheadcomparisonunderclinicalresearchcentreanddailylifeconditions AT bruttomessod accuracyoftwocontinuousglucosemonitoringsystemsaheadtoheadcomparisonunderclinicalresearchcentreanddailylifeconditions AT dollw accuracyoftwocontinuousglucosemonitoringsystemsaheadtoheadcomparisonunderclinicalresearchcentreanddailylifeconditions AT farreta accuracyoftwocontinuousglucosemonitoringsystemsaheadtoheadcomparisonunderclinicalresearchcentreanddailylifeconditions AT galassos accuracyoftwocontinuousglucosemonitoringsystemsaheadtoheadcomparisonunderclinicalresearchcentreanddailylifeconditions AT luijfym accuracyoftwocontinuousglucosemonitoringsystemsaheadtoheadcomparisonunderclinicalresearchcentreanddailylifeconditions AT maderjk accuracyoftwocontinuousglucosemonitoringsystemsaheadtoheadcomparisonunderclinicalresearchcentreanddailylifeconditions AT placej accuracyoftwocontinuousglucosemonitoringsystemsaheadtoheadcomparisonunderclinicalresearchcentreanddailylifeconditions AT boscarif accuracyoftwocontinuousglucosemonitoringsystemsaheadtoheadcomparisonunderclinicalresearchcentreanddailylifeconditions AT piebertr accuracyoftwocontinuousglucosemonitoringsystemsaheadtoheadcomparisonunderclinicalresearchcentreanddailylifeconditions AT renarde accuracyoftwocontinuousglucosemonitoringsystemsaheadtoheadcomparisonunderclinicalresearchcentreanddailylifeconditions AT devriesjh accuracyoftwocontinuousglucosemonitoringsystemsaheadtoheadcomparisonunderclinicalresearchcentreanddailylifeconditions |