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TM-233, a novel analog of 1′-acetoxychavicol acetate, induces cell death in myeloma cells by inhibiting both JAK/STAT and proteasome activities
Although the introduction of bortezomib and immunomodulatory drugs has led to improved outcomes in patients with multiple myeloma, the disease remains incurable. In an effort to identify more potent and well-tolerated agents for myeloma, we have previously reported that 1′-acetoxychavicol acetate (A...
Autores principales: | Sagawa, Morihiko, Tabayashi, Takayuki, Kimura, Yuta, Tomikawa, Tatsuki, Nemoto-Anan, Tomoe, Watanabe, Reiko, Tokuhira, Michihide, Ri, Masaki, Hashimoto, Yuichi, Iida, Shinsuke, Kizaki, Masahiro |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BlackWell Publishing Ltd
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409888/ https://www.ncbi.nlm.nih.gov/pubmed/25613668 http://dx.doi.org/10.1111/cas.12616 |
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