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Potential antitumor therapeutic application of Grimontia hollisae thermostable direct hemolysin mutants
We report on the preparation of a new type of immunotoxin by conjugation of an epidermal growth factor receptor (EGFR)-binding peptide and an R46E mutation of thermostable direct hemolysin from Grimontia hollisae, (Gh-TDH(R)(46E)/EB). The hybrid immunotoxin was purified to homogeneity and showed a s...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BlackWell Publishing Ltd
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409889/ https://www.ncbi.nlm.nih.gov/pubmed/25640743 http://dx.doi.org/10.1111/cas.12623 |