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Association of high-density lipoprotein with development of metabolic syndrome components: a five-year follow-up in adults

BACKGROUND: High-density lipoprotein (HDL) is associated with the incidence of metabolic syndrome (MetS). It is unclear whether subjects with different HDL levels develop different components of MetS over time. Our study aimed to determine what MetS components tend to emerge and change relative to d...

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Autores principales: Liu, Xiangtong, Tao, Lixin, Cao, Kai, Wang, Zhaoping, Chen, Dongning, Guo, Jin, Zhu, Huiping, Yang, Xinghua, Wang, Youxin, Wang, Jingjing, Wang, Chao, Liu, Long, Guo, Xiuhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409998/
https://www.ncbi.nlm.nih.gov/pubmed/25896058
http://dx.doi.org/10.1186/s12889-015-1747-9
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author Liu, Xiangtong
Tao, Lixin
Cao, Kai
Wang, Zhaoping
Chen, Dongning
Guo, Jin
Zhu, Huiping
Yang, Xinghua
Wang, Youxin
Wang, Jingjing
Wang, Chao
Liu, Long
Guo, Xiuhua
author_facet Liu, Xiangtong
Tao, Lixin
Cao, Kai
Wang, Zhaoping
Chen, Dongning
Guo, Jin
Zhu, Huiping
Yang, Xinghua
Wang, Youxin
Wang, Jingjing
Wang, Chao
Liu, Long
Guo, Xiuhua
author_sort Liu, Xiangtong
collection PubMed
description BACKGROUND: High-density lipoprotein (HDL) is associated with the incidence of metabolic syndrome (MetS). It is unclear whether subjects with different HDL levels develop different components of MetS over time. Our study aimed to determine what MetS components tend to emerge and change relative to different levels of HDL. METHODS: During the period 2007 to 2012, 4,905 adults in Tongren and Xiaotangshan Hospitals in Beijing were included with no MetS, self-reported type 2 diabetes, or cardiovascular disease at baseline. An association rule was used to determine the changes of MetS components over time. RESULTS: The incidence of MetS at follow-up was 3.40% for men and 1.50% for women in the high-normal HDL group; 6.65% and 4.55%, respectively, in the normal HDL group; and 11.05% and 6.45%, respectively, in the low HDL group. The most common transition was from healthy to healthy in normal-high or normal HDL groups (47.2% to 63.8%), whereas 11.7% to 39.9% of subjects with low HDL returned to healthy status or stayed unchanged in the low HDL group. The most common new-onset components were elevated blood pressure (9.2 to 10.0%), elevated high-density lipoprotein (5.5 to 11.0%), and raised fasting glucose (5.4 to 5.5%) in the groups with normal-high or normal HDL. CONCLUSIONS: The incidence of MetS increased in parallel with the decrease in HDL. Adults with a low HDL level were more susceptible to developing MetS over time. Low HDL seemed to be a pre-existing phase of MetS and may be a crucial status for MetS prevention.
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spelling pubmed-44099982015-04-27 Association of high-density lipoprotein with development of metabolic syndrome components: a five-year follow-up in adults Liu, Xiangtong Tao, Lixin Cao, Kai Wang, Zhaoping Chen, Dongning Guo, Jin Zhu, Huiping Yang, Xinghua Wang, Youxin Wang, Jingjing Wang, Chao Liu, Long Guo, Xiuhua BMC Public Health Research Article BACKGROUND: High-density lipoprotein (HDL) is associated with the incidence of metabolic syndrome (MetS). It is unclear whether subjects with different HDL levels develop different components of MetS over time. Our study aimed to determine what MetS components tend to emerge and change relative to different levels of HDL. METHODS: During the period 2007 to 2012, 4,905 adults in Tongren and Xiaotangshan Hospitals in Beijing were included with no MetS, self-reported type 2 diabetes, or cardiovascular disease at baseline. An association rule was used to determine the changes of MetS components over time. RESULTS: The incidence of MetS at follow-up was 3.40% for men and 1.50% for women in the high-normal HDL group; 6.65% and 4.55%, respectively, in the normal HDL group; and 11.05% and 6.45%, respectively, in the low HDL group. The most common transition was from healthy to healthy in normal-high or normal HDL groups (47.2% to 63.8%), whereas 11.7% to 39.9% of subjects with low HDL returned to healthy status or stayed unchanged in the low HDL group. The most common new-onset components were elevated blood pressure (9.2 to 10.0%), elevated high-density lipoprotein (5.5 to 11.0%), and raised fasting glucose (5.4 to 5.5%) in the groups with normal-high or normal HDL. CONCLUSIONS: The incidence of MetS increased in parallel with the decrease in HDL. Adults with a low HDL level were more susceptible to developing MetS over time. Low HDL seemed to be a pre-existing phase of MetS and may be a crucial status for MetS prevention. BioMed Central 2015-04-22 /pmc/articles/PMC4409998/ /pubmed/25896058 http://dx.doi.org/10.1186/s12889-015-1747-9 Text en © Liu et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Liu, Xiangtong
Tao, Lixin
Cao, Kai
Wang, Zhaoping
Chen, Dongning
Guo, Jin
Zhu, Huiping
Yang, Xinghua
Wang, Youxin
Wang, Jingjing
Wang, Chao
Liu, Long
Guo, Xiuhua
Association of high-density lipoprotein with development of metabolic syndrome components: a five-year follow-up in adults
title Association of high-density lipoprotein with development of metabolic syndrome components: a five-year follow-up in adults
title_full Association of high-density lipoprotein with development of metabolic syndrome components: a five-year follow-up in adults
title_fullStr Association of high-density lipoprotein with development of metabolic syndrome components: a five-year follow-up in adults
title_full_unstemmed Association of high-density lipoprotein with development of metabolic syndrome components: a five-year follow-up in adults
title_short Association of high-density lipoprotein with development of metabolic syndrome components: a five-year follow-up in adults
title_sort association of high-density lipoprotein with development of metabolic syndrome components: a five-year follow-up in adults
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409998/
https://www.ncbi.nlm.nih.gov/pubmed/25896058
http://dx.doi.org/10.1186/s12889-015-1747-9
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