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Association of high-density lipoprotein with development of metabolic syndrome components: a five-year follow-up in adults
BACKGROUND: High-density lipoprotein (HDL) is associated with the incidence of metabolic syndrome (MetS). It is unclear whether subjects with different HDL levels develop different components of MetS over time. Our study aimed to determine what MetS components tend to emerge and change relative to d...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409998/ https://www.ncbi.nlm.nih.gov/pubmed/25896058 http://dx.doi.org/10.1186/s12889-015-1747-9 |
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author | Liu, Xiangtong Tao, Lixin Cao, Kai Wang, Zhaoping Chen, Dongning Guo, Jin Zhu, Huiping Yang, Xinghua Wang, Youxin Wang, Jingjing Wang, Chao Liu, Long Guo, Xiuhua |
author_facet | Liu, Xiangtong Tao, Lixin Cao, Kai Wang, Zhaoping Chen, Dongning Guo, Jin Zhu, Huiping Yang, Xinghua Wang, Youxin Wang, Jingjing Wang, Chao Liu, Long Guo, Xiuhua |
author_sort | Liu, Xiangtong |
collection | PubMed |
description | BACKGROUND: High-density lipoprotein (HDL) is associated with the incidence of metabolic syndrome (MetS). It is unclear whether subjects with different HDL levels develop different components of MetS over time. Our study aimed to determine what MetS components tend to emerge and change relative to different levels of HDL. METHODS: During the period 2007 to 2012, 4,905 adults in Tongren and Xiaotangshan Hospitals in Beijing were included with no MetS, self-reported type 2 diabetes, or cardiovascular disease at baseline. An association rule was used to determine the changes of MetS components over time. RESULTS: The incidence of MetS at follow-up was 3.40% for men and 1.50% for women in the high-normal HDL group; 6.65% and 4.55%, respectively, in the normal HDL group; and 11.05% and 6.45%, respectively, in the low HDL group. The most common transition was from healthy to healthy in normal-high or normal HDL groups (47.2% to 63.8%), whereas 11.7% to 39.9% of subjects with low HDL returned to healthy status or stayed unchanged in the low HDL group. The most common new-onset components were elevated blood pressure (9.2 to 10.0%), elevated high-density lipoprotein (5.5 to 11.0%), and raised fasting glucose (5.4 to 5.5%) in the groups with normal-high or normal HDL. CONCLUSIONS: The incidence of MetS increased in parallel with the decrease in HDL. Adults with a low HDL level were more susceptible to developing MetS over time. Low HDL seemed to be a pre-existing phase of MetS and may be a crucial status for MetS prevention. |
format | Online Article Text |
id | pubmed-4409998 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-44099982015-04-27 Association of high-density lipoprotein with development of metabolic syndrome components: a five-year follow-up in adults Liu, Xiangtong Tao, Lixin Cao, Kai Wang, Zhaoping Chen, Dongning Guo, Jin Zhu, Huiping Yang, Xinghua Wang, Youxin Wang, Jingjing Wang, Chao Liu, Long Guo, Xiuhua BMC Public Health Research Article BACKGROUND: High-density lipoprotein (HDL) is associated with the incidence of metabolic syndrome (MetS). It is unclear whether subjects with different HDL levels develop different components of MetS over time. Our study aimed to determine what MetS components tend to emerge and change relative to different levels of HDL. METHODS: During the period 2007 to 2012, 4,905 adults in Tongren and Xiaotangshan Hospitals in Beijing were included with no MetS, self-reported type 2 diabetes, or cardiovascular disease at baseline. An association rule was used to determine the changes of MetS components over time. RESULTS: The incidence of MetS at follow-up was 3.40% for men and 1.50% for women in the high-normal HDL group; 6.65% and 4.55%, respectively, in the normal HDL group; and 11.05% and 6.45%, respectively, in the low HDL group. The most common transition was from healthy to healthy in normal-high or normal HDL groups (47.2% to 63.8%), whereas 11.7% to 39.9% of subjects with low HDL returned to healthy status or stayed unchanged in the low HDL group. The most common new-onset components were elevated blood pressure (9.2 to 10.0%), elevated high-density lipoprotein (5.5 to 11.0%), and raised fasting glucose (5.4 to 5.5%) in the groups with normal-high or normal HDL. CONCLUSIONS: The incidence of MetS increased in parallel with the decrease in HDL. Adults with a low HDL level were more susceptible to developing MetS over time. Low HDL seemed to be a pre-existing phase of MetS and may be a crucial status for MetS prevention. BioMed Central 2015-04-22 /pmc/articles/PMC4409998/ /pubmed/25896058 http://dx.doi.org/10.1186/s12889-015-1747-9 Text en © Liu et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Liu, Xiangtong Tao, Lixin Cao, Kai Wang, Zhaoping Chen, Dongning Guo, Jin Zhu, Huiping Yang, Xinghua Wang, Youxin Wang, Jingjing Wang, Chao Liu, Long Guo, Xiuhua Association of high-density lipoprotein with development of metabolic syndrome components: a five-year follow-up in adults |
title | Association of high-density lipoprotein with development of metabolic syndrome components: a five-year follow-up in adults |
title_full | Association of high-density lipoprotein with development of metabolic syndrome components: a five-year follow-up in adults |
title_fullStr | Association of high-density lipoprotein with development of metabolic syndrome components: a five-year follow-up in adults |
title_full_unstemmed | Association of high-density lipoprotein with development of metabolic syndrome components: a five-year follow-up in adults |
title_short | Association of high-density lipoprotein with development of metabolic syndrome components: a five-year follow-up in adults |
title_sort | association of high-density lipoprotein with development of metabolic syndrome components: a five-year follow-up in adults |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409998/ https://www.ncbi.nlm.nih.gov/pubmed/25896058 http://dx.doi.org/10.1186/s12889-015-1747-9 |
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