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Comparison between Unilateral and Bilateral Ovarian Drilling in Clomiphene Citrate Resistance Polycystic Ovary Syndrome Patients: A Randomized Clinical Trial of Efficacy
BACKGROUND: Laparoscopic ovarian drilling (LOD) is an alternative method to induce ovulation in polycystic ovary syndrome (PCOS) patients with clomiphene citrate (CC) resistant instead of gonadotropins. This study aimed to compare the efficacy of unilateral LOD (ULOD) versus bilateral LOD (BLOD) in...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Royan Institute
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4410042/ https://www.ncbi.nlm.nih.gov/pubmed/25918587 |
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author | Zahiri Sorouri, Ziba Sharami, Seyede Hajar Tahersima, Zinab Salamat, Fatemeh |
author_facet | Zahiri Sorouri, Ziba Sharami, Seyede Hajar Tahersima, Zinab Salamat, Fatemeh |
author_sort | Zahiri Sorouri, Ziba |
collection | PubMed |
description | BACKGROUND: Laparoscopic ovarian drilling (LOD) is an alternative method to induce ovulation in polycystic ovary syndrome (PCOS) patients with clomiphene citrate (CC) resistant instead of gonadotropins. This study aimed to compare the efficacy of unilateral LOD (ULOD) versus bilateral LOD (BLOD) in CC resistance PCOS patients in terms of ovulation and pregnancy rates. MATERIALS AND METHODS: In a prospective randomized clinical trial study, we included 100 PCOS patients with CC resistance attending to Al-Zahra Hospital in Rasht, Guilan Province, Iran, from June 2011 to July 2012. Patients were randomly divided into two ULOD and BLOD groups with equal numbers. The clinical and biochemical responses on ovulation and pregnancy rates were assessed over a 6-month follow-up period. RESULTS: Differences in baseline characteristics of patients between two groups prior to laparoscopy were not significant (p>0.05). There were no significant differences between the two groups in terms of clinical and biochemical responses, spontaneous menstruation (66.1 vs. 71.1%), spontaneous ovulation rate (60 vs. 64.4%), and pregnancy rate (33.1 vs. 40%) (p>0.05). Following drilling, there was a significant decrease in mean serum concentrations of luteinizing hormone (LH) (p=0.001) and testosterone (p=0.001) in both the groups. Mean decrease in serum LH (p=0.322) and testosterone concentrations (p=0.079) were not statistically significant between two groups. Mean serum level of follicle stimulating hormone (FSH) did not change significantly in two groups after LOD (p>0.05). CONCLUSION: Based on results of this study, ULOD seems to be equally efficacious as BLOD in terms of ovulation and pregnancy rates (Registration Number: IRCT138903291306N2). |
format | Online Article Text |
id | pubmed-4410042 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Royan Institute |
record_format | MEDLINE/PubMed |
spelling | pubmed-44100422015-04-27 Comparison between Unilateral and Bilateral Ovarian Drilling in Clomiphene Citrate Resistance Polycystic Ovary Syndrome Patients: A Randomized Clinical Trial of Efficacy Zahiri Sorouri, Ziba Sharami, Seyede Hajar Tahersima, Zinab Salamat, Fatemeh Int J Fertil Steril Original Article BACKGROUND: Laparoscopic ovarian drilling (LOD) is an alternative method to induce ovulation in polycystic ovary syndrome (PCOS) patients with clomiphene citrate (CC) resistant instead of gonadotropins. This study aimed to compare the efficacy of unilateral LOD (ULOD) versus bilateral LOD (BLOD) in CC resistance PCOS patients in terms of ovulation and pregnancy rates. MATERIALS AND METHODS: In a prospective randomized clinical trial study, we included 100 PCOS patients with CC resistance attending to Al-Zahra Hospital in Rasht, Guilan Province, Iran, from June 2011 to July 2012. Patients were randomly divided into two ULOD and BLOD groups with equal numbers. The clinical and biochemical responses on ovulation and pregnancy rates were assessed over a 6-month follow-up period. RESULTS: Differences in baseline characteristics of patients between two groups prior to laparoscopy were not significant (p>0.05). There were no significant differences between the two groups in terms of clinical and biochemical responses, spontaneous menstruation (66.1 vs. 71.1%), spontaneous ovulation rate (60 vs. 64.4%), and pregnancy rate (33.1 vs. 40%) (p>0.05). Following drilling, there was a significant decrease in mean serum concentrations of luteinizing hormone (LH) (p=0.001) and testosterone (p=0.001) in both the groups. Mean decrease in serum LH (p=0.322) and testosterone concentrations (p=0.079) were not statistically significant between two groups. Mean serum level of follicle stimulating hormone (FSH) did not change significantly in two groups after LOD (p>0.05). CONCLUSION: Based on results of this study, ULOD seems to be equally efficacious as BLOD in terms of ovulation and pregnancy rates (Registration Number: IRCT138903291306N2). Royan Institute 2015 2015-04-21 /pmc/articles/PMC4410042/ /pubmed/25918587 Text en Any use, distribution, reproduction or abstract of this publication in any medium, with the exception of commercial purposes, is permitted provided the original work is properly cited http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Zahiri Sorouri, Ziba Sharami, Seyede Hajar Tahersima, Zinab Salamat, Fatemeh Comparison between Unilateral and Bilateral Ovarian Drilling in Clomiphene Citrate Resistance Polycystic Ovary Syndrome Patients: A Randomized Clinical Trial of Efficacy |
title | Comparison between Unilateral and Bilateral Ovarian
Drilling in Clomiphene Citrate Resistance Polycystic
Ovary Syndrome Patients: A Randomized Clinical
Trial of Efficacy |
title_full | Comparison between Unilateral and Bilateral Ovarian
Drilling in Clomiphene Citrate Resistance Polycystic
Ovary Syndrome Patients: A Randomized Clinical
Trial of Efficacy |
title_fullStr | Comparison between Unilateral and Bilateral Ovarian
Drilling in Clomiphene Citrate Resistance Polycystic
Ovary Syndrome Patients: A Randomized Clinical
Trial of Efficacy |
title_full_unstemmed | Comparison between Unilateral and Bilateral Ovarian
Drilling in Clomiphene Citrate Resistance Polycystic
Ovary Syndrome Patients: A Randomized Clinical
Trial of Efficacy |
title_short | Comparison between Unilateral and Bilateral Ovarian
Drilling in Clomiphene Citrate Resistance Polycystic
Ovary Syndrome Patients: A Randomized Clinical
Trial of Efficacy |
title_sort | comparison between unilateral and bilateral ovarian
drilling in clomiphene citrate resistance polycystic
ovary syndrome patients: a randomized clinical
trial of efficacy |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4410042/ https://www.ncbi.nlm.nih.gov/pubmed/25918587 |
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