Structure and Biological Functions of β-Hairpin Antimicrobial Peptides

Antimicrobial peptides (AMPs) are evolutionarily ancient factors of the innate immune system that serve as a crucial first line of defense for humans, animals, and plants against infection. This review focuses on the structural organization, biosynthesis, and biological functions of AMPs that posses...

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Autores principales: Panteleev, P. V., Bolosov, I. A., Balandin, S. V., Ovchinnikova, T. V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: A.I. Gordeyev 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4410394/
https://www.ncbi.nlm.nih.gov/pubmed/25927000
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author Panteleev, P. V.
Bolosov, I. A.
Balandin, S. V.
Ovchinnikova, T. V.
author_facet Panteleev, P. V.
Bolosov, I. A.
Balandin, S. V.
Ovchinnikova, T. V.
author_sort Panteleev, P. V.
collection PubMed
description Antimicrobial peptides (AMPs) are evolutionarily ancient factors of the innate immune system that serve as a crucial first line of defense for humans, animals, and plants against infection. This review focuses on the structural organization, biosynthesis, and biological functions of AMPs that possess a β-hairpin spatial structure. Representatives of this class of AMPs are among the most active antibiotic molecules of animal origin. Due to their wide spectrum of activity and resistance to internal environmental factors, natural β-hairpin AMPbased compounds might become the most promising drug candidates.
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spelling pubmed-44103942015-04-29 Structure and Biological Functions of β-Hairpin Antimicrobial Peptides Panteleev, P. V. Bolosov, I. A. Balandin, S. V. Ovchinnikova, T. V. Acta Naturae Research Article Antimicrobial peptides (AMPs) are evolutionarily ancient factors of the innate immune system that serve as a crucial first line of defense for humans, animals, and plants against infection. This review focuses on the structural organization, biosynthesis, and biological functions of AMPs that possess a β-hairpin spatial structure. Representatives of this class of AMPs are among the most active antibiotic molecules of animal origin. Due to their wide spectrum of activity and resistance to internal environmental factors, natural β-hairpin AMPbased compounds might become the most promising drug candidates. A.I. Gordeyev 2015 /pmc/articles/PMC4410394/ /pubmed/25927000 Text en Copyright ® 2015 Park-media Ltd. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Panteleev, P. V.
Bolosov, I. A.
Balandin, S. V.
Ovchinnikova, T. V.
Structure and Biological Functions of β-Hairpin Antimicrobial Peptides
title Structure and Biological Functions of β-Hairpin Antimicrobial Peptides
title_full Structure and Biological Functions of β-Hairpin Antimicrobial Peptides
title_fullStr Structure and Biological Functions of β-Hairpin Antimicrobial Peptides
title_full_unstemmed Structure and Biological Functions of β-Hairpin Antimicrobial Peptides
title_short Structure and Biological Functions of β-Hairpin Antimicrobial Peptides
title_sort structure and biological functions of β-hairpin antimicrobial peptides
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4410394/
https://www.ncbi.nlm.nih.gov/pubmed/25927000
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