Cargando…
Extra pontine osmotic demyelination syndrome
The osmotic demyelination syndrome (ODS) has been identified as a complication of the rapid correction of hyponatremia for decades. However, in recent years, a variety of other medical conditions have been associated with the development of ODS, independent of changes in serum sodium which cause a r...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Indian Academy of Neurosciences
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4410531/ https://www.ncbi.nlm.nih.gov/pubmed/26124552 http://dx.doi.org/10.5214/ans.0972.7531.220212 |
_version_ | 1782368343355817984 |
---|---|
author | Zunga, Pervaiz M Farooq, Omar Dar, Mohd I Dar, Ishrat H Rashid, Samia Rather, Abdul Q Basu, Javid A Ashraf, Mohammed Bhat, Jahangeer A |
author_facet | Zunga, Pervaiz M Farooq, Omar Dar, Mohd I Dar, Ishrat H Rashid, Samia Rather, Abdul Q Basu, Javid A Ashraf, Mohammed Bhat, Jahangeer A |
author_sort | Zunga, Pervaiz M |
collection | PubMed |
description | The osmotic demyelination syndrome (ODS) has been identified as a complication of the rapid correction of hyponatremia for decades. However, in recent years, a variety of other medical conditions have been associated with the development of ODS, independent of changes in serum sodium which cause a rapid changes in osmolality of the interstitial (extracellular) compartment of the brain leading to dehydration of energy-depleted cells with subsequent axonal damage that occurs in characteristic areas. Slow correction of the serum sodium concentration and additional administration of corticosteroids seems to be a major prevention step in ODS patients. In the current report we aimed to share a rare case which we observed in our hospital. A 65 year old female admitted as altered sensorium with history of vomiting, diarrhea was managed with intravenous fluids for 2 days at a peripheral health centre. Patient was referred to our centre with encephalopathy, evaluated and found to have hyponatremia and hypokalemia rest of biochemical parameters and septic profile were normal. Patient’s electrolyte disturbances were managed as per guidelines but encephalopathy persisted. Supportive treatment was continued and patient was discharged after 2 wks of stay in hospital after gaining full sensorium and neurological functions. |
format | Online Article Text |
id | pubmed-4410531 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Indian Academy of Neurosciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-44105312015-06-29 Extra pontine osmotic demyelination syndrome Zunga, Pervaiz M Farooq, Omar Dar, Mohd I Dar, Ishrat H Rashid, Samia Rather, Abdul Q Basu, Javid A Ashraf, Mohammed Bhat, Jahangeer A Ann Neurosci Case Report The osmotic demyelination syndrome (ODS) has been identified as a complication of the rapid correction of hyponatremia for decades. However, in recent years, a variety of other medical conditions have been associated with the development of ODS, independent of changes in serum sodium which cause a rapid changes in osmolality of the interstitial (extracellular) compartment of the brain leading to dehydration of energy-depleted cells with subsequent axonal damage that occurs in characteristic areas. Slow correction of the serum sodium concentration and additional administration of corticosteroids seems to be a major prevention step in ODS patients. In the current report we aimed to share a rare case which we observed in our hospital. A 65 year old female admitted as altered sensorium with history of vomiting, diarrhea was managed with intravenous fluids for 2 days at a peripheral health centre. Patient was referred to our centre with encephalopathy, evaluated and found to have hyponatremia and hypokalemia rest of biochemical parameters and septic profile were normal. Patient’s electrolyte disturbances were managed as per guidelines but encephalopathy persisted. Supportive treatment was continued and patient was discharged after 2 wks of stay in hospital after gaining full sensorium and neurological functions. Indian Academy of Neurosciences 2015-01 /pmc/articles/PMC4410531/ /pubmed/26124552 http://dx.doi.org/10.5214/ans.0972.7531.220212 Text en Copyright © 2015, The National Academy of Sciences http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Zunga, Pervaiz M Farooq, Omar Dar, Mohd I Dar, Ishrat H Rashid, Samia Rather, Abdul Q Basu, Javid A Ashraf, Mohammed Bhat, Jahangeer A Extra pontine osmotic demyelination syndrome |
title | Extra pontine osmotic demyelination syndrome |
title_full | Extra pontine osmotic demyelination syndrome |
title_fullStr | Extra pontine osmotic demyelination syndrome |
title_full_unstemmed | Extra pontine osmotic demyelination syndrome |
title_short | Extra pontine osmotic demyelination syndrome |
title_sort | extra pontine osmotic demyelination syndrome |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4410531/ https://www.ncbi.nlm.nih.gov/pubmed/26124552 http://dx.doi.org/10.5214/ans.0972.7531.220212 |
work_keys_str_mv | AT zungapervaizm extrapontineosmoticdemyelinationsyndrome AT farooqomar extrapontineosmoticdemyelinationsyndrome AT darmohdi extrapontineosmoticdemyelinationsyndrome AT darishrath extrapontineosmoticdemyelinationsyndrome AT rashidsamia extrapontineosmoticdemyelinationsyndrome AT ratherabdulq extrapontineosmoticdemyelinationsyndrome AT basujavida extrapontineosmoticdemyelinationsyndrome AT ashrafmohammed extrapontineosmoticdemyelinationsyndrome AT bhatjahangeera extrapontineosmoticdemyelinationsyndrome |