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Single-molecule chemo-mechanical unfolding reveals multiple transition state barriers in a small single-domain protein
A fundamental question in protein folding is whether proteins fold through one or multiple trajectories. While most experiments indicate a single pathway, simulations suggest proteins can fold through many parallel pathways. Here, we use a combination of chemical denaturant, mechanical force and sit...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Pub. Group
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4410640/ https://www.ncbi.nlm.nih.gov/pubmed/25882479 http://dx.doi.org/10.1038/ncomms7861 |