ATRX Plays a Key Role in Maintaining Silencing at Interstitial Heterochromatic Loci and Imprinted Genes

Histone H3.3 is a replication-independent histone variant, which replaces histones that are turned over throughout the entire cell cycle. H3.3 deposition at euchromatin is dependent on HIRA, whereas ATRX/Daxx deposits H3.3 at pericentric heterochromatin and telomeres. The role of H3.3 at heterochrom...

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Detalles Bibliográficos
Autores principales: Voon, Hsiao P.J., Hughes, Jim R., Rode, Christina, De La Rosa-Velázquez, Inti A., Jenuwein, Thomas, Feil, Robert, Higgs, Douglas R., Gibbons, Richard J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4410944/
https://www.ncbi.nlm.nih.gov/pubmed/25865896
http://dx.doi.org/10.1016/j.celrep.2015.03.036

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