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Profile of tedizolid phosphate and its potential in the treatment of acute bacterial skin and skin structure infections
Tedizolid phosphate is the first once-daily oxazolidinone approved by the United States Food and Drug Administration for the treatment of acute bacterial skin and skin structure infections (ABSSSI). It is more potent in vitro than linezolid against methicillin-resistant Staphylococcus aureus (MRSA)...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Dove Medical Press
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411017/ https://www.ncbi.nlm.nih.gov/pubmed/25960671 http://dx.doi.org/10.2147/IDR.S56691 |
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author | Hall, Ronald G Michaels, Heidi N |
author_facet | Hall, Ronald G Michaels, Heidi N |
author_sort | Hall, Ronald G |
collection | PubMed |
description | Tedizolid phosphate is the first once-daily oxazolidinone approved by the United States Food and Drug Administration for the treatment of acute bacterial skin and skin structure infections (ABSSSI). It is more potent in vitro than linezolid against methicillin-resistant Staphylococcus aureus (MRSA) and other gram-positive pathogens causing ABSSSI, even retaining activity against some linezolid-resistant strains. Tedizolid is approximately 90% protein bound, leading to lower free-drug concentrations than linezolid. The impact of the effect of food, renal or hepatic insufficiency, or hemodialysis on tedizolid’s pharmacokinetic have been evaluated, and no dosage adjustment is needed in these populations. In animal and clinical studies, tedizolid’s effect on bacterial killing is optimized by the free-drug area under the curve to minimum inhibitory concentration ratio (fAUC/MIC). The 200 mg once-daily dose is able to achieve the target fAUC/MIC ratio in 98% of simulated patients. Two Phase III clinical trials have demonstrated the noninferiority of tedizolid 200 mg once daily for 6 days to linezolid 600 mg twice daily for 10 days. In vitro, animal, and clinical studies have failed to demonstrate that tedizolid inhibits monoamine oxidase to a clinically relevant extent. Tedizolid has several key advantages over linezolid including once daily dosing, decreased treatment duration, minimal interaction with serotonergic agents, possibly associated with less adverse events associated with the impairment of mitochondrial protein synthesis (eg, myelosuppression, lactic acidosis, and peripheral/optic neuropathies), and retains in vitro activity against linezolid-resistant gram-positive bacteria. Economic analyses with tedizolid are needed to describe the cost-effectiveness of this agent compared with other options used for ABSSSI, particularly treatment options active against MRSA. |
format | Online Article Text |
id | pubmed-4411017 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-44110172015-05-08 Profile of tedizolid phosphate and its potential in the treatment of acute bacterial skin and skin structure infections Hall, Ronald G Michaels, Heidi N Infect Drug Resist Review Tedizolid phosphate is the first once-daily oxazolidinone approved by the United States Food and Drug Administration for the treatment of acute bacterial skin and skin structure infections (ABSSSI). It is more potent in vitro than linezolid against methicillin-resistant Staphylococcus aureus (MRSA) and other gram-positive pathogens causing ABSSSI, even retaining activity against some linezolid-resistant strains. Tedizolid is approximately 90% protein bound, leading to lower free-drug concentrations than linezolid. The impact of the effect of food, renal or hepatic insufficiency, or hemodialysis on tedizolid’s pharmacokinetic have been evaluated, and no dosage adjustment is needed in these populations. In animal and clinical studies, tedizolid’s effect on bacterial killing is optimized by the free-drug area under the curve to minimum inhibitory concentration ratio (fAUC/MIC). The 200 mg once-daily dose is able to achieve the target fAUC/MIC ratio in 98% of simulated patients. Two Phase III clinical trials have demonstrated the noninferiority of tedizolid 200 mg once daily for 6 days to linezolid 600 mg twice daily for 10 days. In vitro, animal, and clinical studies have failed to demonstrate that tedizolid inhibits monoamine oxidase to a clinically relevant extent. Tedizolid has several key advantages over linezolid including once daily dosing, decreased treatment duration, minimal interaction with serotonergic agents, possibly associated with less adverse events associated with the impairment of mitochondrial protein synthesis (eg, myelosuppression, lactic acidosis, and peripheral/optic neuropathies), and retains in vitro activity against linezolid-resistant gram-positive bacteria. Economic analyses with tedizolid are needed to describe the cost-effectiveness of this agent compared with other options used for ABSSSI, particularly treatment options active against MRSA. Dove Medical Press 2015-04-22 /pmc/articles/PMC4411017/ /pubmed/25960671 http://dx.doi.org/10.2147/IDR.S56691 Text en © 2015 Hall and Michaels. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Review Hall, Ronald G Michaels, Heidi N Profile of tedizolid phosphate and its potential in the treatment of acute bacterial skin and skin structure infections |
title | Profile of tedizolid phosphate and its potential in the treatment of acute bacterial skin and skin structure infections |
title_full | Profile of tedizolid phosphate and its potential in the treatment of acute bacterial skin and skin structure infections |
title_fullStr | Profile of tedizolid phosphate and its potential in the treatment of acute bacterial skin and skin structure infections |
title_full_unstemmed | Profile of tedizolid phosphate and its potential in the treatment of acute bacterial skin and skin structure infections |
title_short | Profile of tedizolid phosphate and its potential in the treatment of acute bacterial skin and skin structure infections |
title_sort | profile of tedizolid phosphate and its potential in the treatment of acute bacterial skin and skin structure infections |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411017/ https://www.ncbi.nlm.nih.gov/pubmed/25960671 http://dx.doi.org/10.2147/IDR.S56691 |
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