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Passive Smoking and Breast Cancer Risk among Non-Smoking Women: A Case-Control Study in China

BACKGROUND: The role of passive smoking on breast cancer risk was unclear. This study aimed to evaluate the association between passive smoking and breast cancer risk among Chinese women. METHODS/PRINCIPAL FINDINGS: A hospital-based case-control study, including 877 breast cancer cases and 890 contr...

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Autores principales: Li, Bin, Wang, Lian, Lu, Min-Shan, Mo, Xiong-Fei, Lin, Fang-Yu, Ho, Suzanne C., Zhang, Cai-Xia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411087/
https://www.ncbi.nlm.nih.gov/pubmed/25915759
http://dx.doi.org/10.1371/journal.pone.0125894
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author Li, Bin
Wang, Lian
Lu, Min-Shan
Mo, Xiong-Fei
Lin, Fang-Yu
Ho, Suzanne C.
Zhang, Cai-Xia
author_facet Li, Bin
Wang, Lian
Lu, Min-Shan
Mo, Xiong-Fei
Lin, Fang-Yu
Ho, Suzanne C.
Zhang, Cai-Xia
author_sort Li, Bin
collection PubMed
description BACKGROUND: The role of passive smoking on breast cancer risk was unclear. This study aimed to evaluate the association between passive smoking and breast cancer risk among Chinese women. METHODS/PRINCIPAL FINDINGS: A hospital-based case-control study, including 877 breast cancer cases and 890 controls, frequency-matched by age and residence, was conducted. A structured questionnaire was used to collect information on passive smoking history through face-to-face interview by trained interviewers. Unconditional logistic regression models were used to estimate the association between passive smoking and breast cancer risk. A positive association between any passive smoking exposure and breast cancer risk was observed. Compared with women who were never exposed to passive smoking, women who were ever exposed had a higher breast cancer risk, with the adjusted odds ratio (OR) and 95% confidence interval (CI) of 1.35 (1.11-1.65). Similar result was found on home passive smoking exposure and breast cancer risk, but not on workplace passive smoking exposure. Women who were ever exposed to tobacco smoke at home had a higher risk of breast cancer compared with never exposed women, with the adjusted OR (95% CI) of 1.30 (1.05-1.61). Home passive smoking exposure showed significant dose-response relationships with breast cancer risk in smoker-years, cigarettes/day and total pack-years (P (trend)=0.003, 0.006 and 0.009, respectively). An increased total smoker-years of any passive exposure significantly elevated the risk of breast cancer (P (trend)<0.001). Positive associations and dose-response relationships were found among postmenopausal women and all subtypes of estrogen receptor (ER) and progesterone receptor (PR) status of breast cancer. CONCLUSIONS: Passive smoking was associated with an increased risk of breast cancer among non-smoking Chinese women. A stronger positive association with breast cancer risk was seen mainly among postmenopausal women.
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spelling pubmed-44110872015-05-07 Passive Smoking and Breast Cancer Risk among Non-Smoking Women: A Case-Control Study in China Li, Bin Wang, Lian Lu, Min-Shan Mo, Xiong-Fei Lin, Fang-Yu Ho, Suzanne C. Zhang, Cai-Xia PLoS One Research Article BACKGROUND: The role of passive smoking on breast cancer risk was unclear. This study aimed to evaluate the association between passive smoking and breast cancer risk among Chinese women. METHODS/PRINCIPAL FINDINGS: A hospital-based case-control study, including 877 breast cancer cases and 890 controls, frequency-matched by age and residence, was conducted. A structured questionnaire was used to collect information on passive smoking history through face-to-face interview by trained interviewers. Unconditional logistic regression models were used to estimate the association between passive smoking and breast cancer risk. A positive association between any passive smoking exposure and breast cancer risk was observed. Compared with women who were never exposed to passive smoking, women who were ever exposed had a higher breast cancer risk, with the adjusted odds ratio (OR) and 95% confidence interval (CI) of 1.35 (1.11-1.65). Similar result was found on home passive smoking exposure and breast cancer risk, but not on workplace passive smoking exposure. Women who were ever exposed to tobacco smoke at home had a higher risk of breast cancer compared with never exposed women, with the adjusted OR (95% CI) of 1.30 (1.05-1.61). Home passive smoking exposure showed significant dose-response relationships with breast cancer risk in smoker-years, cigarettes/day and total pack-years (P (trend)=0.003, 0.006 and 0.009, respectively). An increased total smoker-years of any passive exposure significantly elevated the risk of breast cancer (P (trend)<0.001). Positive associations and dose-response relationships were found among postmenopausal women and all subtypes of estrogen receptor (ER) and progesterone receptor (PR) status of breast cancer. CONCLUSIONS: Passive smoking was associated with an increased risk of breast cancer among non-smoking Chinese women. A stronger positive association with breast cancer risk was seen mainly among postmenopausal women. Public Library of Science 2015-04-27 /pmc/articles/PMC4411087/ /pubmed/25915759 http://dx.doi.org/10.1371/journal.pone.0125894 Text en © 2015 Li et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Li, Bin
Wang, Lian
Lu, Min-Shan
Mo, Xiong-Fei
Lin, Fang-Yu
Ho, Suzanne C.
Zhang, Cai-Xia
Passive Smoking and Breast Cancer Risk among Non-Smoking Women: A Case-Control Study in China
title Passive Smoking and Breast Cancer Risk among Non-Smoking Women: A Case-Control Study in China
title_full Passive Smoking and Breast Cancer Risk among Non-Smoking Women: A Case-Control Study in China
title_fullStr Passive Smoking and Breast Cancer Risk among Non-Smoking Women: A Case-Control Study in China
title_full_unstemmed Passive Smoking and Breast Cancer Risk among Non-Smoking Women: A Case-Control Study in China
title_short Passive Smoking and Breast Cancer Risk among Non-Smoking Women: A Case-Control Study in China
title_sort passive smoking and breast cancer risk among non-smoking women: a case-control study in china
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411087/
https://www.ncbi.nlm.nih.gov/pubmed/25915759
http://dx.doi.org/10.1371/journal.pone.0125894
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