Cargando…

Ruling out pyridine dinucleotides as true TRPM2 channel activators reveals novel direct agonist ADP-ribose-2′-phosphate

Transient receptor potential melastatin 2 (TRPM2), a Ca(2+)-permeable cation channel implicated in postischemic neuronal cell death, leukocyte activation, and insulin secretion, is activated by intracellular ADP ribose (ADPR). In addition, the pyridine dinucleotides nicotinamide-adenine-dinucleotide...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tóth, Balázs, Iordanov, Iordan, Csanády, László
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2015
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411260/ https://www.ncbi.nlm.nih.gov/pubmed/25918360 http://dx.doi.org/10.1085/jgp.201511377

Ejemplares similares

The proposed channel-enzyme transient receptor potential melastatin 2 does not possess ADP ribose hydrolase activity
por: Iordanov, Iordan, et al.
Publicado: (2016)

Selective profiling of N- and C-terminal nucleotide-binding sites in a TRPM2 channel
por: Tóth, Balázs, et al.
Publicado: (2020)

Enzyme activity and selectivity filter stability of ancient TRPM2 channels were simultaneously lost in early vertebrates
por: Iordanov, Iordan, et al.
Publicado: (2019)

Estimating the true stability of the prehydrolytic outward-facing state in an ABC protein
por: Simon, Márton A, et al.
Publicado: (2023)

A Cell Permeable NPE Caged ADP-Ribose for Studying TRPM2
por: Yu, Peilin, et al.
Publicado: (2012)

Simple binding of protein kinase A prior to phosphorylation allows CFTR anion channels to be opened by nucleotides
por: Mihályi, Csaba, et al.
Publicado: (2020)

ADP-Ribose and oxidative stress activate TRPM8 channel in prostate cancer and kidney cells
por: Baş, Ercan, et al.
Publicado: (2019)

Structure of a TRPM2 channel in complex with Ca(2+) explains unique gating regulation
por: Zhang, Zhe, et al.
Publicado: (2018)

Does Cyclic ADP-Ribose (cADPR) Activate the Non-selective Cation Channel TRPM2?
por: Fliegert, Ralf, et al.
Publicado: (2020)

ADP-ribose/TRPM2-mediated Ca(2+) signaling is essential for cytolytic degranulation and antitumor activity of natural killer cells
por: Rah, So-Young, et al.
Publicado: (2015)

CD38/ADP-ribose/TRPM2-mediated nuclear Ca(2+) signaling is essential for hepatic gluconeogenesis in fasting and diabetes
por: Rah, So-Young, et al.
Publicado: (2023)

ADP-Ribose Activates the TRPM2 Channel from the Sea Anemone Nematostella vectensis Independently of the NUDT9H Domain
por: Kühn, Frank J. P., et al.
Publicado: (2016)

Dual amplification strategy turns TRPM2 channels into supersensitive central heat detectors
por: Bartók, Ádám, et al.
Publicado: (2022)

Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and Cyclic ADP-Ribose (cADPR) Mediate Ca(2+) Signaling in Cardiac Hypertrophy Induced by β-Adrenergic Stimulation
por: Gul, Rukhsana, et al.
Publicado: (2016)

Four Ca(2+) Ions Activate TRPM2 Channels by Binding in Deep Crevices near the Pore but Intracellularly of the Gate
por: Csanády, László, et al.
Publicado: (2009)

Molecular Bases of Catalysis and ADP-Ribose Preference of Human Mn(2+)-Dependent ADP-Ribose/CDP-Alcohol Diphosphatase and Conversion by Mutagenesis to a Preferential Cyclic ADP-Ribose Phosphohydrolase
por: Cabezas, Alicia, et al.
Publicado: (2015)

Specific cyclic ADP-ribose phosphohydrolase obtained by mutagenic engineering of Mn(2+)-dependent ADP-ribose/CDP-alcohol diphosphatase
por: Ribeiro, João Meireles, et al.
Publicado: (2018)

Different Principles of ADP-Ribose-Mediated Activation and Opposite Roles of the NUDT9 Homology Domain in the TRPM2 Orthologs of Man and Sea Anemone
por: Kühn, Frank, et al.
Publicado: (2017)

Cyclic ADP-Ribose and Heat Regulate Oxytocin Release via CD38 and TRPM2 in the Hypothalamus during Social or Psychological Stress in Mice
por: Zhong, Jing, et al.
Publicado: (2016)

The Arabidopsis thaliana Poly(ADP-Ribose) Polymerases 1 and 2 Modify DNA by ADP-Ribosylating Terminal Phosphate Residues
por: Taipakova, Sabira, et al.
Publicado: (2020)

Proteome-wide identification of poly(ADP-ribose) binding proteins and poly(ADP-ribose)-associated protein complexes
por: Gagné, Jean-Philippe, et al.
Publicado: (2008)

8-Bromo-cyclic inosine diphosphoribose: towards a selective cyclic ADP-ribose agonist
por: Kirchberger, Tanja, et al.
Publicado: (2009)

Inhibition of nicotinamide dinucleotide salvage pathway counters acquired and intrinsic poly(ADP-ribose) polymerase inhibitor resistance in high-grade serous ovarian cancer
por: Sauriol, Alexandre, et al.
Publicado: (2023)

Pancreatic β-Cell Death, Regeneration and Insulin Secretion: Roles of Poly(ADP-Ribose) Polymerase and Cyclic ADP-Ribose
por: Takasawa, Shin, et al.
Publicado: (2002)

Poly(ADP-ribose): An organizer of cellular architecture
por: Leung, Anthony K.L.
Publicado: (2014)

Poly (ADP-ribose) in the pathogenesis of Parkinson's disease
por: Lee, Yunjong, et al.
Publicado: (2014)

RNA regulation by Poly(ADP-ribose) polymerases
por: Bock, Florian J., et al.
Publicado: (2015)

Oncogenic activity of poly (ADP-ribose) glycohydrolase
por: Marques, Maud, et al.
Publicado: (2018)

Mitotic functions of poly(ADP-ribose) polymerases
por: Slade, Dea
Publicado: (2019)

The Antiviral Activities of Poly-ADP-Ribose Polymerases
por: Malgras, Mathilde, et al.
Publicado: (2021)

ARH Family of ADP-Ribose-Acceptor Hydrolases
por: Ishiwata-Endo, Hiroko, et al.
Publicado: (2022)

Mutations of human DNA topoisomerase I at poly(ADP-ribose) binding sites: modulation of camptothecin activity by ADP-ribose polymers
por: Tesauro, Cinzia, et al.
Publicado: (2014)

Inhibition of Poly ADP-Ribose Glycohydrolase Sensitizes Ovarian Cancer Cells to Poly ADP-Ribose Polymerase Inhibitors and Platinum Agents
por: Matanes, Emad, et al.
Publicado: (2021)

Stability of centrosome numbers in poly(ADP-ribose) polymerase-1- and poly(ADP-ribose) glycohydrolase-deficient mouse ES cells
por: Ogino, Hideki, et al.
Publicado: (2004)

Deletion of poly(ADP-ribose) polymerase-1 changes the composition of the microbiome in the gut
por: Vida, András, et al.
Publicado: (2018)

Synthesis of Terminal Ribose Analogues of Adenosine 5′-Diphosphate Ribose as Probes for the Transient Receptor Potential Cation Channel TRPM2
por: Baszczyňski, Ondřej, et al.
Publicado: (2019)

New Facets in the Regulation of Gene Expression by ADP-Ribosylation and Poly(ADP-ribose) Polymerases
por: Ryu, Keun Woo, et al.
Publicado: (2015)

Engineering Af1521 improves ADP-ribose binding and identification of ADP-ribosylated proteins
por: Nowak, Kathrin, et al.
Publicado: (2020)

Selective monitoring of the protein-free ADP-ribose released by ADP-ribosylation reversal enzymes
por: Kasson, Samuel, et al.
Publicado: (2021)

Molecular Insights into Poly(ADP-ribose) Recognition and Processing
por: Žaja, Roko, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_atgt758pvpu5kprn9k8nrfpn7k