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Relative Specificity: All Substrates Are Not Created Equal

A biological molecule, e.g., an enzyme, tends to interact with its many cognate substrates, targets, or partners differentially. Such a property is termed relative specificity and has been proposed to regulate important physiological functions, even though it has not been examined explicitly in most...

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Detalles Bibliográficos
Autor principal: Zeng, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411342/
https://www.ncbi.nlm.nih.gov/pubmed/24491634
http://dx.doi.org/10.1016/j.gpb.2014.01.001
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author Zeng, Yan
author_facet Zeng, Yan
author_sort Zeng, Yan
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description A biological molecule, e.g., an enzyme, tends to interact with its many cognate substrates, targets, or partners differentially. Such a property is termed relative specificity and has been proposed to regulate important physiological functions, even though it has not been examined explicitly in most complex biochemical systems. This essay reviews several recent large-scale studies that investigate protein folding, signal transduction, RNA binding, translation and transcription in the context of relative specificity. These results and others support a pervasive role of relative specificity in diverse biological processes. It is becoming clear that relative specificity contributes fundamentally to the diversity and complexity of biological systems, which has significant implications in disease processes as well.
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spelling pubmed-44113422015-05-06 Relative Specificity: All Substrates Are Not Created Equal Zeng, Yan Genomics Proteomics Bioinformatics Review A biological molecule, e.g., an enzyme, tends to interact with its many cognate substrates, targets, or partners differentially. Such a property is termed relative specificity and has been proposed to regulate important physiological functions, even though it has not been examined explicitly in most complex biochemical systems. This essay reviews several recent large-scale studies that investigate protein folding, signal transduction, RNA binding, translation and transcription in the context of relative specificity. These results and others support a pervasive role of relative specificity in diverse biological processes. It is becoming clear that relative specificity contributes fundamentally to the diversity and complexity of biological systems, which has significant implications in disease processes as well. Elsevier 2014-02 2014-01-31 /pmc/articles/PMC4411342/ /pubmed/24491634 http://dx.doi.org/10.1016/j.gpb.2014.01.001 Text en © 2014 Beijing Institute of Genomics, Chinese Academy of Sciences and Genetics Society of China. Production and hosting by Elsevier B.V. All rights reserved. http://creativecommons.org/licenses/by-nc-sa/3.0/ This is an open access article under the CC BY-NC-SA license (http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Review
Zeng, Yan
Relative Specificity: All Substrates Are Not Created Equal
title Relative Specificity: All Substrates Are Not Created Equal
title_full Relative Specificity: All Substrates Are Not Created Equal
title_fullStr Relative Specificity: All Substrates Are Not Created Equal
title_full_unstemmed Relative Specificity: All Substrates Are Not Created Equal
title_short Relative Specificity: All Substrates Are Not Created Equal
title_sort relative specificity: all substrates are not created equal
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411342/
https://www.ncbi.nlm.nih.gov/pubmed/24491634
http://dx.doi.org/10.1016/j.gpb.2014.01.001
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