The aberrant overexpression of vimentin is linked to a more aggressive status in tumours of the gastrointestinal tract

Vimentin is an intermediate filament protein normally expressed in cells of mesenchymal origin, e.g. myofibroblasts, chondrocytes, macrophages, and endothelial cells. The expression of vimentin, which has been thought of as the main mesenchymal marker, is also detected in tumour tissue. In tumours o...

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Detalles Bibliográficos
Autores principales: Brzozowa, Marlena, Wyrobiec, Grzegorz, Kołodziej, Izabela, Sitarski, Mateusz, Matysiak, Natalia, Reichman-Warmusz, Edyta, Żaba, Małgorzata, Wojnicz, Romuald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2015
Materias:
Review Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411408/
https://www.ncbi.nlm.nih.gov/pubmed/25960808
http://dx.doi.org/10.5114/pg.2014.47502
Descripción
Sumario:Vimentin is an intermediate filament protein normally expressed in cells of mesenchymal origin, e.g. myofibroblasts, chondrocytes, macrophages, and endothelial cells. The expression of vimentin, which has been thought of as the main mesenchymal marker, is also detected in tumour tissue. In tumours of the gastrointestinal tract vimentin expression is usually correlated with advanced stage of tumour, lymph node metastasis, and patient survival.

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