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The Involvement of GAS6 Signaling in the Development of Obesity and Associated Inflammation
Growth arrest-specific 6 (GAS6), a vitamin K-dependent protein, plays a role in the survival, proliferation, migration, differentiation, adhesion, and apoptosis of cells. GAS6 is highly expressed during growth arrest, followed by a sharp decrease during differentiation in adipocytes. The functions o...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411443/ https://www.ncbi.nlm.nih.gov/pubmed/25954309 http://dx.doi.org/10.1155/2015/202513 |
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author | Wu, Kuo-Sheng Hung, Yi-Jen Lee, Chien-Hsing Hsiao, Fone-Ching Hsieh, Po-Shiuan |
author_facet | Wu, Kuo-Sheng Hung, Yi-Jen Lee, Chien-Hsing Hsiao, Fone-Ching Hsieh, Po-Shiuan |
author_sort | Wu, Kuo-Sheng |
collection | PubMed |
description | Growth arrest-specific 6 (GAS6), a vitamin K-dependent protein, plays a role in the survival, proliferation, migration, differentiation, adhesion, and apoptosis of cells. GAS6 is highly expressed during growth arrest, followed by a sharp decrease during differentiation in adipocytes. The functions of GAS6 signaling are limited to TAM (Tyro3, Axl, and Mer) receptors and are dependent on the cell type. While many studies have focused on the role of GAS6 in inflammation and cancer, only few studies focused on its roles of GAS6 in obesity. Accordingly, the participation of GAS6 in the progression of obesity remains controversial. In this review, we summarize the results of current studies from clinical and basic research to elucidate the possible role of GAS6 signaling in obesity and associated disorders. In addition, this summary may offer a direction to develop clinical therapeutic strategies for the prevention and treatment of obesity and related complications. |
format | Online Article Text |
id | pubmed-4411443 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-44114432015-05-07 The Involvement of GAS6 Signaling in the Development of Obesity and Associated Inflammation Wu, Kuo-Sheng Hung, Yi-Jen Lee, Chien-Hsing Hsiao, Fone-Ching Hsieh, Po-Shiuan Int J Endocrinol Review Article Growth arrest-specific 6 (GAS6), a vitamin K-dependent protein, plays a role in the survival, proliferation, migration, differentiation, adhesion, and apoptosis of cells. GAS6 is highly expressed during growth arrest, followed by a sharp decrease during differentiation in adipocytes. The functions of GAS6 signaling are limited to TAM (Tyro3, Axl, and Mer) receptors and are dependent on the cell type. While many studies have focused on the role of GAS6 in inflammation and cancer, only few studies focused on its roles of GAS6 in obesity. Accordingly, the participation of GAS6 in the progression of obesity remains controversial. In this review, we summarize the results of current studies from clinical and basic research to elucidate the possible role of GAS6 signaling in obesity and associated disorders. In addition, this summary may offer a direction to develop clinical therapeutic strategies for the prevention and treatment of obesity and related complications. Hindawi Publishing Corporation 2015 2015-04-14 /pmc/articles/PMC4411443/ /pubmed/25954309 http://dx.doi.org/10.1155/2015/202513 Text en Copyright © 2015 Kuo-Sheng Wu et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Wu, Kuo-Sheng Hung, Yi-Jen Lee, Chien-Hsing Hsiao, Fone-Ching Hsieh, Po-Shiuan The Involvement of GAS6 Signaling in the Development of Obesity and Associated Inflammation |
title | The Involvement of GAS6 Signaling in the Development of Obesity and Associated Inflammation |
title_full | The Involvement of GAS6 Signaling in the Development of Obesity and Associated Inflammation |
title_fullStr | The Involvement of GAS6 Signaling in the Development of Obesity and Associated Inflammation |
title_full_unstemmed | The Involvement of GAS6 Signaling in the Development of Obesity and Associated Inflammation |
title_short | The Involvement of GAS6 Signaling in the Development of Obesity and Associated Inflammation |
title_sort | involvement of gas6 signaling in the development of obesity and associated inflammation |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411443/ https://www.ncbi.nlm.nih.gov/pubmed/25954309 http://dx.doi.org/10.1155/2015/202513 |
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