Human coronavirus OC43 3CL protease and the potential of ML188 as a broad-spectrum lead compound: Homology modelling and molecular dynamic studies

BACKGROUND: The coronavirus 3 chymotrypsin-like protease (3CL(pro)) is a validated target in the design of potential anticoronavirus inhibitors. The high degree of homology within the protease’s active site and substrate conservation supports the identification of broad spectrum lead compounds. A pr...

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Detalles Bibliográficos
Autores principales: Berry, Michael, Fielding, Burtram, Gamieldien, Junaid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411765/
https://www.ncbi.nlm.nih.gov/pubmed/25928480
http://dx.doi.org/10.1186/s12900-015-0035-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411765/
https://www.ncbi.nlm.nih.gov/pubmed/25928480
http://dx.doi.org/10.1186/s12900-015-0035-3

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