Cephazolin-Induced Toxic Epidermal Necrolysis Treated with Intravenous Immunoglobulin and N-Acetylcysteine

Toxic epidermal necrolysis is the most severe form of drug-induced skin reaction and includes denudation of >30% of total body surface area. The mechanism of disease is not completely understood, but immunologic mechanisms, cytotoxic reactions, and delayed hypersensitivity seem to be involved. We...

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Autores principales: Saavedra, Carlos, Cárdenas, Paola, Castellanos, Héctor, Contreras, Kateir, Castro, J. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411878/
https://www.ncbi.nlm.nih.gov/pubmed/25954556
http://dx.doi.org/10.1155/2012/931528
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author Saavedra, Carlos
Cárdenas, Paola
Castellanos, Héctor
Contreras, Kateir
Castro, J. R.
author_facet Saavedra, Carlos
Cárdenas, Paola
Castellanos, Héctor
Contreras, Kateir
Castro, J. R.
author_sort Saavedra, Carlos
collection PubMed
description Toxic epidermal necrolysis is the most severe form of drug-induced skin reaction and includes denudation of >30% of total body surface area. The mechanism of disease is not completely understood, but immunologic mechanisms, cytotoxic reactions, and delayed hypersensitivity seem to be involved. We report a case of cephazolin-induced toxic epidermal necrolysis treated with intravenous immunoglobulin and N-acetylcysteine with excellent response.
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spelling pubmed-44118782015-05-07 Cephazolin-Induced Toxic Epidermal Necrolysis Treated with Intravenous Immunoglobulin and N-Acetylcysteine Saavedra, Carlos Cárdenas, Paola Castellanos, Héctor Contreras, Kateir Castro, J. R. Case Reports Immunol Case Report Toxic epidermal necrolysis is the most severe form of drug-induced skin reaction and includes denudation of >30% of total body surface area. The mechanism of disease is not completely understood, but immunologic mechanisms, cytotoxic reactions, and delayed hypersensitivity seem to be involved. We report a case of cephazolin-induced toxic epidermal necrolysis treated with intravenous immunoglobulin and N-acetylcysteine with excellent response. Hindawi Publishing Corporation 2012 2012-04-19 /pmc/articles/PMC4411878/ /pubmed/25954556 http://dx.doi.org/10.1155/2012/931528 Text en Copyright © 2012 Carlos Saavedra et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Saavedra, Carlos
Cárdenas, Paola
Castellanos, Héctor
Contreras, Kateir
Castro, J. R.
Cephazolin-Induced Toxic Epidermal Necrolysis Treated with Intravenous Immunoglobulin and N-Acetylcysteine
title Cephazolin-Induced Toxic Epidermal Necrolysis Treated with Intravenous Immunoglobulin and N-Acetylcysteine
title_full Cephazolin-Induced Toxic Epidermal Necrolysis Treated with Intravenous Immunoglobulin and N-Acetylcysteine
title_fullStr Cephazolin-Induced Toxic Epidermal Necrolysis Treated with Intravenous Immunoglobulin and N-Acetylcysteine
title_full_unstemmed Cephazolin-Induced Toxic Epidermal Necrolysis Treated with Intravenous Immunoglobulin and N-Acetylcysteine
title_short Cephazolin-Induced Toxic Epidermal Necrolysis Treated with Intravenous Immunoglobulin and N-Acetylcysteine
title_sort cephazolin-induced toxic epidermal necrolysis treated with intravenous immunoglobulin and n-acetylcysteine
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411878/
https://www.ncbi.nlm.nih.gov/pubmed/25954556
http://dx.doi.org/10.1155/2012/931528
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